The molecular and cellular basis of neurodegenerative diseases : underlying mechanisms / edited by Michael S. Wolfe.
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prio...
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| Format: | eBook |
| Language: | English |
| Published: |
London :
Academic Press is an imprint of Elsevier,
[2018]
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Table of Contents:
- Front Cover; The Molecular and Cellular Basis of Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Preface; 1 Solving the Puzzle of Neurodegeneration; Introduction: The General Problem of Neurodegeneration; Epidemiology and Clinical Presentation; Molecular Pathology; Genetics; Molecular Clues to Mechanisms of Pathogenesis; Common Themes and Controversies in Neurodegeneration; Animal Models; Prospects for Therapeutics; Conclusions and Perspective; References; 2 Prion Diseases; Introduction and Historical Perspective.
- 3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying MechanismsQuantitative Approach to Basic AD Demographics; Change Over Time: (i) Biogenesis, Production, and Turnover of Aβ; Change Over Time: (ii) The Accumulation, Spread, Propagation of Aβ; Change Over Time: (iii) The Growth and Accumulation of Plaque Cores; Change Over Time: (iv) Brain Atrophy; Change Over Time: (v) Cognition; Clearance Mechanisms and Impaired Phagocytosis; Calculating Polygenic Risk Scores.
- Mitochondrial Energy ProductionRNA Metabolism; Axonal Dysfunction; Excitotoxicity; Oxidative Stress; Neuroinflammation; Other TDP-43 Proteinopathies; Frontotemporal Dementia; TDP-43 in Alzheimer's Disease and Parkinsonian Syndromes; Inclusion Body Myositis; Conclusions; References; 6 Parkinson's Disease and Other Synucleinopathies; Introduction: The Pathology of Parkinson's Disease; Protein Deposition; Aggregation of α-Synuclein in PD; The Broader Set of Synucleinopathies; Changes in Cellularity; Neuronal Loss; Reactive Gliosis; Genes Associated with Synucleinopathies.
- Disease-Modifying Strategies: Models of Aβ Accumulation in Alzheimer's Disease-Implications for Aβ Amyloid-Targeting TherapiesReferences; 4 Neurodegeneration and the Ordered Assembly of Tau; Introduction; Tau Isoforms; Tau Aggregation; Genetics of MAPT; Propagation of Tau Aggregates; Strains of Aggregated Tau; Acknowledgments; References; Further Reading; 5 Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies; TDP-43 Biology; Amyotrophic Lateral Sclerosis; ALS-TDP-43; ALS-SOD1; ALS-FUS; ALS-C9ORF72; Mechanisms Dysregulated; Nucleocytoplasmic Transport; Proteostasis Clearance.
- Molecular Mechanism of Prion PropagationThe Cellular Prion Protein: Structure and Proteolytic Processing; Physiological Function of PrPC; Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity; Human Prion Diseases; Animal Prion Diseases; Prion Strains and Species Barriers; Methods for Propagation and Detection of Prions; Therapeutic Approaches; PrPC and the Alzheimer's Aβ Peptide; Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases; Concluding Remarks; References.