Hepatitis B virus and liver disease / Jia-Horng Kao, Ding-Shinn Chen, editors.
This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progr...
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Full Text (via Springer) |
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Published: |
Singapore :
Springer,
2018.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Hepatitis B virus and liver disease / |c Jia-Horng Kao, Ding-Shinn Chen, editors. |
| 264 | 1 | |a Singapore : |b Springer, |c 2018. | |
| 300 | |a 1 online resource. | ||
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| 500 | |a Includes index. | ||
| 505 | 0 | |a Intro; Foreword; Preface; Contents; List of Contributors; 1: Molecular Virology and Life Cycle; 1 Classification; 2 Structure of the Hepatitis B Virus; 2.1 Viral and Subviral Particles; 2.2 Genome Organization and Viral Proteins; 2.2.1 Pol ORF; 2.2.2 Pre-C/C ORF; HBc Protein; HBe Protein; 2.2.3 Pre-S/S ORF; SHBs; MHBs; LHBs; 2.2.4 X ORF; 3 Viral Life Cycle; 3.1 Attachment and Penetration; 3.2 Conversion of Genomic RC DNA into cccDNA and Transcriptional Activation of the Viral Minichromosome; 3.3 Genomic Replication via Reverse Transcription. | |
| 505 | 8 | |a 3.4 Virion Assembly and Release4 Variant Viruses; 4.1 Precore Mutants; 4.2 Basal Core Promoter Mutants; 4.3 Polymerase Mutants; 4.3.1 l-Nucleoside Analogue Resistance; 4.3.2 Acyclic Nucleoside Phosphonate Resistance; 4.3.3 d-Cyclopentane Resistance; 4.3.4 Multidrug Resistance; 4.4 Envelope Mutants; References; 2: Unmet Needs in Basic Research: In Vitro and In Vivo Models; 1 Introduction; 1.1 Hepatitis B Virus; 1.2 Woodchuck Hepatitis Virus; 1.3 Duck Hepatitis B Virus; 2 HBV In Vivo Experimental Models; 2.1 Chimpanzee Model; 2.2 Macaque Model; 2.3 Tupaia Model. | |
| 505 | 8 | |a 2.4 Transgenic Mice2.5 Human Hepatocyte Chimeric Mice; 2.6 Immune-Competent Mouse Models; 2.7 Hydrodynamic Injection HBV Mouse Model; 2.8 Adenovirus-Mediated Delivery; 3 HBV In Vitro Experimental Systems; 3.1 Primary Human Hepatocytes; 3.2 HepG2 Cells; 3.3 HepaRG Cells; 3.4 HepCHLine-4 Cells; 3.5 Identification of the HBV Receptor; 3.6 NTCP Expression as a Limiting Factor for HBV Infection; 3.7 NTCP-Expressing Cell Lines; 3.8 Human Hepatocytes Isolated from Humanized Mice; 3.9 Improvements to Primary Hepatocyte Culturing. | |
| 505 | 8 | |a 3.10 Hepatic Cell Lines Derived from Human-Induced Pluripotent Stem CellsReferences; 3: Immunopathogenesis of Hepatitis B Virus (HBV) Infection; 1 Characteristics of Immune Response in Acute-Resolved HBV Infection; 1.1 The Innate Immune Response; 1.1.1 HBV: Is It Sensed or Not by the Innate Immune System?; 1.1.2 NK Cells: The Main Force of Innate Immunity; 1.2 The Adaptive Immune Response; 1.2.1 B Cells; 1.2.2 T Cells; 2 Specialties of the Immune Response in Chronic HBV Infection; 2.1 The Innate Immune Response in CHB; 2.2 The Adaptive Immune Response in CHB. | |
| 505 | 8 | |a 2.2.1 B Cells2.2.2 T Cells: Functional Exhaustion; 3 Immune Response and Liver Injury; 3.1 HBV-Specific T Cells; 3.2 Non-HBV-Specific Cells; 4 Immune Response and Antiviral Treatment; References; 4: Epidemiology and Natural History of Chronic Hepatitis B Virus Infection; 1 Introduction; 2 Epidemiology; 2.1 CHB in Africa; 2.2 CHB in Asia and the Pacific Islands; 2.3 CHB in the Americas; 2.4 CHB in Europe; 3 HBV Genotypes; 4 Natural History; 5 Interpretation of Serologies; 6 HBV Structure and Replication Cycle; 7 Phases of Infection; References. | |
| 520 | |a This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed January 18, 2018) | |
| 650 | 0 | |a Hepatitis B virus. |0 http://id.loc.gov/authorities/subjects/sh85060298. | |
| 650 | 0 | |a Liver |x Diseases. |0 http://id.loc.gov/authorities/subjects/sh85077755. | |
| 650 | 7 | |a Hepatitis B virus. |2 fast |0 (OCoLC)fst00955211. | |
| 650 | 7 | |a Liver |x Diseases. |2 fast |0 (OCoLC)fst01000640. | |
| 700 | 1 | |a Kao, Jia-Horng, |e editor. |0 http://id.loc.gov/authorities/names/n2018184252. | |
| 700 | 1 | |a Chen, Ding-Shinn, |e editor. |0 http://id.loc.gov/authorities/names/n2016188599. | |
| 776 | 0 | 8 | |i Printed edition: |z 9789811048425. |
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