Gold(I, III) complexes designed for selective targeting and inhibition of zinc finger proteins / Raphael Enoque Ferraz de Paiva.
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N̂N and ĈN donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the huma...
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| Online Access: |
Full Text (via Springer) |
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| Main Author: | |
| Other title: | Gold (one, three) complexes designed for selective targeting and inhibition of zinc finger proteins. |
| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
[2018]
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| Series: | Springer theses,
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| Subjects: |
| Summary: | This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N̂N and ĈN donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling. |
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| Item Description: | "Doctoral thesis accepted by the University of Caminas, Campinas, Brazil." |
| Physical Description: | 1 online resource (XXXIX, 151 pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references. |
| ISBN: | 3030008533 9783030008536 9783030008543 3030008541 |
| ISSN: | 2190-5053. |
| Source of Description, Etc. Note: | Online resource; title from digital title page (viewed on November 16, 2018) |