Gold(I, III) complexes designed for selective targeting and inhibition of zinc finger proteins / Raphael Enoque Ferraz de Paiva.
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N̂N and ĈN donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the huma...
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Full Text (via Springer) |
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| Main Author: | |
| Other title: | Gold (one, three) complexes designed for selective targeting and inhibition of zinc finger proteins. |
| Format: | eBook |
| Language: | English |
| Published: |
Cham, Switzerland :
Springer,
[2018]
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| Series: | Springer theses,
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| Subjects: |
MARC
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| 245 | 1 | 0 | |a Gold(I, III) complexes designed for selective targeting and inhibition of zinc finger proteins / |c Raphael Enoque Ferraz de Paiva. |
| 246 | 3 | |a Gold (one, three) complexes designed for selective targeting and inhibition of zinc finger proteins. | |
| 264 | 1 | |a Cham, Switzerland : |b Springer, |c [2018] | |
| 300 | |a 1 online resource (XXXIX, 151 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
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| 490 | 1 | |a Springer Theses, Recognizing Outstanding Ph. D. Research, |x 2190-5053. | |
| 500 | |a "Doctoral thesis accepted by the University of Caminas, Campinas, Brazil." | ||
| 504 | |a Includes bibliographical references. | ||
| 505 | 0 | |a Au(I)-phosphine series design -- Probing the Protein: Ion Mobility Spectrometry -- Probing Gold: X-ray Absorption Spectroscopy -- Probing Cells: Cytotoxicity Evaluation -- Au(III) series with k2C, N and k2N, N' ligands -- "Dual Probe" X-ray Absorption Spectroscopy. | |
| 520 | |a This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N̂N and ĈN donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling. | ||
| 588 | 0 | |a Online resource; title from digital title page (viewed on November 16, 2018) | |
| 650 | 0 | |a Gold compounds |x Therapeutic use. | |
| 650 | 0 | |a Zinc-finger proteins. | |
| 650 | 7 | |a Gold compounds. |2 fast |0 (OCoLC)fst00944423. | |
| 650 | 7 | |a Zinc-finger proteins. |2 fast |0 (OCoLC)fst01184452. | |
| 776 | 0 | 8 | |i Print version: |z 9783030008529. |
| 776 | 0 | 8 | |i Print version: |z 9783030008543. |
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