Targeting Notch in Cancer : From the Fruit Fly to the Clinic / Lucio Miele, Spyros Artavanis-Tsakonas, editors.
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Full Text (via Springer) |
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
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New York, NY :
Springer,
2018.
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Table of Contents:
- 3.5 Notch Functions as Tumor Suppressor3.5.1 Notch Tumor Suppressor in the Skin: A General Paradigm; 3.6 Notch Functions as a Tumor Suppressor in SCC; 3.6.1 Dual Function of Notch in Lung Cancer; 3.7 Novel Tumor-Suppressive Roles for Notch Signaling Activity in Urothelial Cancers and Glioblastoma; 3.8 Conclusions; References; Chapter 4: Out on the Fringe: Modulation of Notch Signaling by Glycosylation; 4.1 Introduction; 4.2 Controlling Notch Activation Through Glycosylation; 4.3 Preparing Notch for Fringe: The Role of Fucosylation.
- 4.4 The Specificity of Ligand-Receptor Interaction and the Role of Specific EGF-Like Repeats4.5 Pofut1, Fringe, and Direct Modification of Ligand EGF-Like Repeats; 4.6 Vertebrate Fringe Proteins in Paraxial Mesoderm Segmentation; 4.7 Cell-Autonomous and Non-cell-Autonomous Regulation of Notch and Its Ligands by Fringe Proteins; 4.8 Hematopoiesis and Lymphocyte Development: The Role of Lfng and Mfng; 4.9 Role of Lfng and Mfng in Mammary Gland Development and Breast Cancer; 4.10 Roles of Lfng and Mfng in Lung Development and Lung Cancer; 4.11 Tumor-Suppressive Role of Lfng in Pancreatic Cancer.
- Intro; Preface; Contents; Chapter 1: Structural Biology of Notch Signaling; 1.1 Introduction; 1.2 Signal Initiation by Ligand Binding to Notch; 1.2.1 Ligand-Binding Region of Notch Receptors; 1.2.2 Notch Ligands; 1.2.3 Initiation of Notch Activation by Notch/Ligand Interactions; 1.3 Ligand Endocytosis Mediated by E3 Ubiquitin Ligases; 1.4 Release from Autoinhibition in the Negative Regulatory Region of Notch; 1.5 Cleavage by ADAM Family Metalloproteases at Site S2; 1.6 Cleavage by γ-Secretase at Site S3; 1.7 Transcriptional Activation and Assembly of Notch Nuclear Complexes.
- 1.7.1 The DNA-Binding Protein CSL1.7.2 Assembly of the Notch Transcription Complex (NTC); 1.7.3 Dimeric Assembly of Notch Transcription Complexes; 1.7.4 Intracellular Notch Repressor Complexes; 1.8 Summary; References; Chapter 2: Noncanonical Notch Signaling; 2.1 Introduction; 2.2 Noncanonical, Cytosolic Notch Signaling; 2.2.1 Notch and Deltex; 2.2.2 An Early Description of RBPJ-Independent Notch Signaling; 2.2.3 Notch and Abl; 2.2.4 Notch in Apoptosis and Cell Survival; 2.2.5 Notch and Akt; 2.2.6 Notch and β-Catenin; 2.3 Noncanonical, Nuclear Notch Signaling.
- 2.4 Notch and NF-κB: A Player in Both Cytosolic and Nuclear Noncanonical Notch Signaling2.4.1 Notch/NF-κB Interactions in the Cytosol; 2.4.2 Notch/NF-κB Interactions in the Nucleus; 2.5 Other Forms of Noncanonical Notch Signaling; 2.6 Concluding Remarks; References; Chapter 3: Dual Function of Notch Signaling in Cancer: Oncogene and Tumor Suppressor; 3.1 A Brief Introduction to the Notch Cascade; 3.2 Notch Functions as Oncoprotein; 3.3 Oncogenic Notch-Driven Signaling Events: T-ALL as Paradigm; 3.4 Changing Metabolism Is Part of the Oncogenic Notch Program.