HIV-1 [electronic resource] : molecular biology and pathogenesis : viral mechanisms : the first of a two-volume set / edited by Kuan-Teh Jeang.
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology...
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| Online Access: |
Full Text (via ScienceDirect) |
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| Other title: | Viral mechanisms |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
San Diego, Calif. :
Academic Press,
2000.
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| Series: | Advances in pharmacology (San Diego, Calif.) ;
v. 48. |
| Subjects: |
MARC
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| 245 | 0 | 0 | |a HIV-1 |h [electronic resource] : |b molecular biology and pathogenesis : viral mechanisms : the first of a two-volume set / |c edited by Kuan-Teh Jeang. |
| 246 | 3 | 0 | |a Viral mechanisms |
| 260 | |a San Diego, Calif. : |b Academic Press, |c 2000. | ||
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| 490 | 1 | |a Advances in pharmacology ; |v v. 48 | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines. The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Key Features. Detailed insights into viral packaging, expression, and assembly. Mechanistic understanding of how HIV interacts with receptors and infects cells. Delineation of virally encoded regulatory processes unique to HIV. Clinical Applications:. An updated review of current chemotherapeutics for HIV. New concepts in the discovery and design of novel anti-HIV drugs. The latest developments in HIV-vaccine research. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover; HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms; Copyright Page; Contents; Contributors; Preface; Chapter 1. HIV RNA Packaging and Lentivirus-Based Vectors; I. Introduction; II. HIV RNA Packaging; III. Summary; References; Chapter 2. Multiple Biological Roles Associated with the Repeat (R) Region of the HIV-1 RNA Genome; I. Introduction; II. Transcription; III. Polyadenylation; IV. mRNA Translation; V. RNA Dimerization/Packaging; VI. Reverse Transcription; VII. Perspective and Future Directions; References | |
| 505 | 8 | |a Chapter 3. HIV Accessory Proteins: Multifunctional Components of a Complex SystemI. Introduction; II. Vif: A Potent Regulator of Viral Infectivity; III. Functional Domains in Vif; IV. Vif Associates with the Cytoskeleton; V. Vif as a Possible Regulator of Gag/Pol Polyprotein Processing; VI. Virion-Associated Vif May Have a Crucial Role in Regulating Viral Infectivity; VII. Vpr and Vpx; VIII. Vpr as a Transcriptional Activator; IX. Vpr as a Coactivator of the Glucocorticoid Receptor; X. Vpr-Induced Cell-Cycle Arrest; XI. Nuclear Import; XII. The Multifunctional Nef Protein | |
| 505 | 8 | |a XIII. Downregulation of Cell-Surface CD4XIV. Downregulation of MHC Class I; XV. Enhancement of Viral Infectivity; XVI. Acceleration of Disease Progression; XVII. HIV-1-Specific Vpu Protein; XVIII. Vpu-Mediated CD4 Degradation; XIX. Enhancement of Viral Particle Release; References; Chapter 4. Role of Chromatin in HIV-1 Transcriptional Regulation; I. Introduction; II. HIV-1 Transcriptional Regulatory Elements; III. Chromatin Is an Integral Component of the Transcriptional Regulatory Apparatus; IV. HIV-1 Retroviral Integration and Chromatin; V. DNase I-Hypersensitive Sites in the HIV-1 Genome | |
| 505 | 8 | |a VI. Nucleosomes Are Precisely Positioned in the 5 LTRVII. Disruption of a Single Nucleosome at the Transcription Start Site during HIV-1 Transcriptional Activation; VIII. Two Novel Regulatory Regions Are Associated with DNase I-Hypersensitive Sites in the HIV-1 Provirus; IX. Role of Histone Acetylation/Deacetylation in HIV-1 Transcriptional Regulation; X. Role of Tat in HIV-1 Promoter Chromatin Remodeling and Transcriptional Activation; XI. Study of HIV-1 Transcription using in vitro Chromatin- Reconstituted Templates; XII. Conclusions; References | |
| 546 | |a English. | ||
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