Basic methods handbook for clinical orthopaedic research : a practical guide and case based research approach / Volker Musahl, Jón Karlsson, Michael T. Hirschmann, Olufemi R. Ayeni, Robert G. Marx, Jason L. Koh, Norimasa Nakamura, editors.
This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant a...
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| Format: | eBook |
| Language: | English |
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Berlin, Germany :
Springer,
2019.
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MARC
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| 245 | 0 | 0 | |a Basic methods handbook for clinical orthopaedic research : |b a practical guide and case based research approach / |c Volker Musahl, Jón Karlsson, Michael T. Hirschmann, Olufemi R. Ayeni, Robert G. Marx, Jason L. Koh, Norimasa Nakamura, editors. |
| 264 | 1 | |a Berlin, Germany : |b Springer, |c 2019. | |
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| 505 | 0 | |a Intro; Contents; About the Editors; Part I: Evidence Based Medicine in Orthopaedics; 1: What Is Evidence-Based Medicine?; 1.1 History of EBM; 1.2 What Defines the Practice of EBM?; 1.3 The Best Available Evidence; 1.3.1 The Hierarchy of Evidence; 1.3.2 Evaluation of Hypothesis Testing; 1.4 Let Evidence-Based Research Impact Clinical Work; 1.5 The Future for EBM; References; 2: What Is the Hierarchy of Clinical Evidence?; 2.1 Introduction: Why Do We Need a Hierarchy?; 2.2 The Hierarchy of Evidence and Study Selection; 2.3 Primary/Unfiltered Research; 2.3.1 Expert Opinion. | |
| 505 | 8 | |a 2.3.2 Case Report2.3.3 Cross-sectional Study; 2.3.4 Case-Control Study; 2.3.5 Cohort Study; 2.3.6 Randomized Controlled Trial (RCT); 2.4 Secondary/Filtered Research; 2.4.1 Systematic Review; 2.4.2 Systematic Review with Meta-analysis; 2.4.3 PRISMA; 2.5 Levels of Evidence; 2.6 Trends in the Evolution of Orthopedic Literature; 2.7 Additional Resources and Websites; References; 3: Bias and Confounding; 3.1 Introduction: What Is Bias?; 3.2 Biases in the Study Design Phase; 3.2.1 Conceptual Bias; 3.2.2 Confounding Bias; 3.2.2.1 Measuring and Controlling Confounding Factors. | |
| 505 | 8 | |a 3.2.2.2 Restriction3.2.2.3 Matching; 3.2.2.4 Avoiding Bias Due to Confounding Factors; 3.3 Biases in the Patient Recruitment Phase; 3.3.1 Selection Bias; 3.3.2 Retention Bias; 3.4 Informational Biases in the Data Collection Phase; 3.4.1 Detection or Measurement Bias; 3.4.2 Response Bias; 3.5 Biases in the Analysis and Data Interpretation Phase; 3.5.1 Propensity Scores; 3.6 Publication Bias; References; 4: Ethical Consideration in Orthopedic Research; 4.1 Introduction; 4.2 History; 4.3 Institutional Review Board (IRB); 4.4 Privacy Regulations: The United States and Europe. | |
| 505 | 8 | |a 4.5 Informed Consent4.6 Evaluation of Human Research Protocols; 4.7 Responsibilities of Principal Investigator; 4.8 Sham Surgery; 4.9 Funding and Potential Conflict of Interest (COI); References; 5: Conflict of Interest; 5.1 Introduction; 5.2 Definition of Conflict of Interest; 5.3 Recognition and Consequences of Conflict of Interest; 5.4 Management of Conflict of Interest; References; 6: Ethics in Clinical Research; 6.1 Introduction; 6.1.1 Tuskegee Syphilis Experiment; 6.2 Regulatory and Ethical Guidelines in Clinical Research; 6.2.1 Declaration of Helsinki; 6.2.2 Common Rule. | |
| 505 | 8 | |a 6.2.3 Institutional Review Board6.2.4 HIPAA; 6.3 Ethical Population Representation; 6.4 Ethical Publishing Practices; 6.4.1 Data Fraud and Misconduct; 6.4.2 Conflict of Interest; 6.4.3 Self-Citation; 6.4.4 Predatory Journals; References; Part II: How to Get Started with Clinical Research?; 7: How to Get Started: From Idea to Research Question; 7.1 Research Questions and the Decisions We Make Every Day; 7.2 The Importance of a Research Question; 7.3 Types of Research Questions; 7.4 Identifying Knowledge Gaps; 7.5 The PICO Approach; 7.5.1 Patient; 7.5.2 Intervention. | |
| 520 | |a This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS. | ||
| 588 | 0 | |a Online resource; title from PDF title page (SpringerLink, viewed February 5, 2019) | |
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| 700 | 1 | |a Musahl, Volker, |e editor. |0 http://id.loc.gov/authorities/names/nb2013005128 |1 http://isni.org/isni/0000000016034310. | |
| 700 | 1 | |a Karlsson, Jon, |e editor. |0 http://id.loc.gov/authorities/names/n2003129761 |1 http://isni.org/isni/0000000038809391. | |
| 700 | 1 | |a Hirschmann, Michael T., |e editor. |0 http://id.loc.gov/authorities/names/n2016181818. | |
| 700 | 1 | |a Ayeni, Olufemi R., |e editor. |0 http://id.loc.gov/authorities/names/n2016190587. | |
| 700 | 1 | |a Marx, Robert G., |e editor. | |
| 700 | 1 | |a Koh, Jason L., |e editor. | |
| 700 | 1 | |a Nakamura, Norimasa, |e editor. |0 http://id.loc.gov/authorities/names/n2014187130. | |
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