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Crystallographic and modeling methods in molecular design / Charles E. Bugg, Steven E. Ealick, editors.

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Bibliographic Details
Online Access: Full Text (via Internet Archive)
Corporate Authors: University of Alabama at Birmingham. Department of Biochemistry, Crystallographic and Modeling Methods in Molecular Design Symposium
Other Authors: Bugg, Charles E., Ealick, Steven E.
Format: Conference Proceeding eBook
Language:English
Published: New York : Springer-Verlag, ℗♭1990.
Subjects:
Drugs > Design > Congresses.
Drugs > Mathematical models > Congresses.
Crystallography > Congresses.
Molecular structure > Congresses.
crystallography.
Cristallographie.
Conception de medicaments.
Modele moleculaire.
Crystallography.
Drugs > Design.
Drugs > Mathematical models.
Molecular structure.
Congresses.
Conference papers and proceedings.
Table of Contents:
  • Inhibitor binding to thymidylate synthase is mediated by different structural determinants than those that promote tight binding to dihydrofolate reductase / David A. Matthews, Cheryl A. Janson and Ward W. Smith
  • Crystallographic and pharmacological studies of antiviral agents against human rhinovirus / Thomas J. Smith [and others]
  • Structural studies of elastase-inhibitor complexes with gbs-lactams / Manuel A. Navia, Brian M. McKeever and James P. Springer
  • Design of purine nucleoside phosphorylase inhibitors using X-ray crystallography / Steven E. Ealick [and others]
  • The potential role of solvation in the dihydrofolate reductase species selectivity of trimethoprim / Lee F. Kuyper
  • Crystallographic and genetic approaches toward the design of proteins of enhanced thermostability / J.A. Wozniak [and others]
  • (Cont) Stability of folded conformations by computer simulation / Jan Hermans, R.-H Yun and Amil G. Anderson
  • The use of molecular dynamics and free energy perturbation approaches in simulating the properties of macromolecules and their binding to ligands / Peter A. Kollman
  • Molecular recognition of DNA minor groove binding drugs / Andrew H.-J Wang and Mai-kun Teng
  • Structural and computational studies of anticonvulsants : a search for correlation between molecular systematics and activity / Penelope W. Codding [and others]
  • Crystallography and molecular mechanics in designing drugs with unknown receptor structure / David J. Duchamp
  • Molecular modeling with substructure libraries derived from known protein structures / Barry C. Finzel [and others]
  • (Cont) O : a macromolecule modeling environment / T. Alwyn Jones, Marc Bergdoll and Morten Kjeldgaard
  • Inhibitor design from known structure / Renee L. DesJarlais [and others]
  • The Cambridge structural database in molecular modeling / Frank H. Allen and Michael J. Doyle
  • Preferred interaction patterns from crystallographic databases / R. Scott Rowland [and others]
  • Aladdin : a real tool for structure-based drug design / Yvonne C. Martin.

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