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Biochemistry of cardiovascular dysfunction in obesity / Paramjit S. Tappia, Sukhwinder K. Bhullar, Naranjan S. Dhalla, editors.

Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead t...

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Bibliographic Details
Online Access: Full Text (via Springer)
Other Authors: Tappia, Paramjit S. (Editor), Bhullar, Sukhwinder K. (Editor), Dhalla, Naranjan S. (Editor)
Format: eBook
Language:English
Published: Cham, Switzerland : Springer, [2020]
Series:Advances in biochemistry in health and disease ; v. 20.
Subjects:
Cardiovascular system > Diseases.
Cardiovascular system > Pathophysiology.
Obesity > Complications.
Human physiology.
Table of Contents:
  • Intro
  • Preface
  • Contents
  • Contributors
  • Part IPathophysiology of Cardiovascular Complications in Obesity
  • 1 Different Faces of Obesity in Cardiovascular Diseases: Culprit or Protector
  • Introduction and Epidemiology
  • Definition
  • Obesity and Cardiovascular Disease
  • Obesity and CVD Risk Factors
  • Metabolic Syndrome
  • Diabetes Mellitus
  • Hypertension
  • Dyslipidemia
  • Obesity and Atrial Fibrillation
  • Obesity and Heart Failure
  • Obesity and Depression and Physical Activity
  • Obesity Paradox
  • Conclusions
  • References.
  • 2 Obesity-Induced Cardiovascular Complications and Therapeutic Intervention
  • Introduction
  • Obesity Paradox
  • Epidemiology of Obesity and Cardiovascular Complication
  • Obesity-Induced Cardiovascular Complications: Role of Adipose Tissues
  • Adverse Effects of Obesity on the Cardiovascular System
  • Heart Failure
  • Atherosclerosis
  • Coronary Artery Disease
  • Haemodynamic Changes
  • Hypertension
  • Pulmonary Arterial Hypertension
  • Cardiac Hypertrophy
  • Congenital Heart Disease
  • Cardiac Arrhythmias and Sudden Cardiac Death
  • Myocardial Infarction.
  • NAFLD Is a Risk Factor for Cardiovascular Complications in Obesity
  • Prevention and Treatment Options for the Management of Obesity and CVD
  • Conclusions
  • References
  • 3 Maternal Obesity: Impacts on the Cardiovascular Health of Mother and Offspring
  • Introduction
  • Cardiovascular Risks Associated with Maternal Obesity
  • Maternal Hypertension and Cardiac Dysfunction
  • Congenital Heart Defects
  • Mechanisms of Maternal Obesity and Related Cardiovascular Complications in Their Offspring
  • Hormone-Mediated Responses
  • Inflammation-Mediated Responses
  • Oxidative Stress-Mediated Responses.
  • Clinical Management of Maternal Obesity
  • References
  • 4 Role of Liver X Receptor in Cardiovascular Diseases
  • Introduction
  • Liver X Receptors
  • Physiological Functions of LXRs
  • LXR in Cardiovascular Diseases
  • Atherosclerosis
  • Myocardial Ischemia/Repurfusion Injury (MI/RI)
  • Diabetic Cardiomyopathy (DCM)
  • Cardiac Hypertrophy
  • Cardiac Fibrosis
  • Conclusions
  • References
  • 5 Role of NLRP3 Inflammasomes in Obesity-Induced Cardiovascular Diseases
  • Introduction
  • NLRP3 Inflammasome as a Sensor of Inflammation.
  • Activation of Inflammasome in Obesity-Induced Cardiovascular Diseases
  • The NLRP3 Inflammasome and Obesity
  • The NLRP3 Inflammasome in Obesity Induced Cardiovascular Diseases
  • NLRP3 Inflammasome in Atherosclerosis
  • NLRP3 Inflammasome in Hypertension
  • NLRP3 Inflammasome in Myocardial Infarction and Cardiac Remodeling
  • Therapeutic Strategies Targeting Inflammasome
  • Summary
  • References
  • 6 Vicious Link of Obesity with Cardiometabolic and Renal Diseases
  • Introduction
  • Obesity-Induced Cardiovascular Disorders
  • Obesity-Induced T2D and Associated Complications.

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