Producing biomolecular substances with fermenters, bioreactors, and biomolecular synthesizers [electronic resource] / William L. Hochfeld.

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Bibliographic Details
Online Access: Full Text (via Taylor & Francis)
Main Author: Hochfeld, William L.
Other title:BIOSCIENCEnetBASE.
Format: Electronic eBook
Language:English
Published: Boca Raton, FL : CRC/Taylor & Francis, 2006.
Subjects:

MARC

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245 1 0 |a Producing biomolecular substances with fermenters, bioreactors, and biomolecular synthesizers  |h [electronic resource] /  |c William L. Hochfeld. 
260 |a Boca Raton, FL :  |b CRC/Taylor & Francis,  |c 2006. 
300 |a 1 online resource (383 pages) :  |b illustrations. 
336 |a text  |b txt  |2 rdacontent. 
337 |a computer  |b c  |2 rdamedia. 
338 |a online resource  |b cr  |2 rdacarrier. 
504 |a Includes bibliographical references (pages 357-372) and index. 
505 0 |a Introduction ; Biotechnology; Bioproduction; The Bioprocess; Cell Lines; Cell-Culture Process; Separation, Recovery, 
505 0 |a Purification; Virus and Foreign-DNA Removal; Quality Assurance; Technology Overview ; Biomolecular Foundations; Cellular Variation; Key Molecular Interactions; Base-Pair Complementarity; Genetic Coding; Interrupting Gene Segments; Sequence Determinations; Cloning; Synthesized DNA; Cell Lines; Expression Systems Introduction to the Bioprocess ; Overview; Optimizing Product Yield; Kinetic Models; cGMP Standards; Contract Manufacturing; Complex Mixtures; Biomolecular Products; Joint Manufacturing; Downscaling to Scale Up; Large-Scale Bioprocesses; Scaling-Up In-House or in a Contract Facility; Lab-to-Pilot-Plant-to-Production; Increasing Bioprocess Scale; Differing Features at Larger Scale; Simulating Environment at Scale; Detailed Specifications; Impact on Downstream Bioprocessing; FDA Biologics Review Process. 
505 0 |a ; Regulating Biological Products Recombinant DNA Materials and Methods ; Cloning; Applications; Screening and Selection; DNA Synthesis; Cell Lines; Expression Systems; Vector Construction; Prokaryotic and Eukaryotic Growth Characteristics; Expression Levels; Intra- vs. 
505 0 |a Extra-cellular Expression; Intracellular Expression; Extracellular Expression; Glycosylation; Mammalian Cell Glycosylation; Insect Cell Glycosylation; General Considerations; Further Post-translational Modifications; Economic Concerns; Regulatory Concerns; Manufacturers' Directory Enzymes ; Overview; Enzyme Protein Engineering; Transformation in Non-Aqueous Systems; Restriction Enzymes; Restriction-Enzyme Classes; Class I Restriction Enzymes; Class II Restriction Enzymes; Class III Restriction Enzymes; Restriction-Enzyme Specificity; Star Activity; Enzyme Families and Compatible Ends; Isoschizomers; Reverse Transcriptases; DNA and RNA Nucleases; Manufacturers' Directory DNA-Amplification Reagents ; Overview; Amplification by DNA Synthesis (PCR); Amplification by RNA Transcription (TAS and 3SR; Amplification by Ligation (LAR, LCR, 
505 0 |a LAS); Amplification by RNA Replication (Q Replicase); Sequence-Based Amplification; Manufacturers Directory Cell-Culture Media ; Overview; Prokaryotic Cell-Culture Medium; Eukaryotic Cell-Culture Medium; Defined Medium; Serum; Other Sera; Serum Contamination; Serum-Free (Defined) Medium; Cell-Culture Gels; Media Supplements; Attachment Factors; Buffers; Sodium; Earle's Balanced Salt Solution; Growth Factors; Epidermal Growth Factor (EGF); Fibroblast Growth Factors (FGF); Acidic FGF; Basic FGF; Other Growth Factors; Lectins; Toxins; Transport Factors; Vitamins; Water; Manufacturers' Directory Fermenters ; Introduction to Fermentation; Historical Perspective; The Fermentation Process; Enzyme Fermentation in the Organic Phase; Cell Growth and Production; Factors Affecting Specific Growth Rate; Kinetic. 
505 0 |a Models; Optimal Conditions; Recombinant Culture Kinetics; Fermenter Design; Kinetic Modeling of the Fermentation Process; STF Batch Scale Up; Power Number Method for STF Geometric Scale Up; Continuous-Culture Scale Up; Fermenter Manufacturers Directory Bioreactors ; Introduction; Aseptic Conditions; Monoclonal Antibody Production; mAB Production in Ascites Fluid; Bioreactor Engineering and Design; Bioreactors II: Kinetic Modeling and Bioreactor Dynamics and Bioreactor Design Program; Bioreactor Manufacturers Directory Biomolecular Synthesizers ; DNA Synthesizers; Manufacturers Directory; Technology Overview; Peptides by Solid-Phase Synthesis; Manufacturers Directory; Biotechnology Glossary ; References and Recommended Reading Index. 
588 0 |a Print version record. 
650 0 |a Biomolecules  |x Synthesis. 
650 0 |a Bioreactors.  |0 http://id.loc.gov/authorities/subjects/sh87005835. 
650 7 |a Biomolecules  |x Synthesis.  |2 fast  |0 (OCoLC)fst01424701. 
650 7 |a Bioreactors.  |2 fast  |0 (OCoLC)fst00832686. 
730 0 |a BIOSCIENCEnetBASE. 
776 0 8 |i Print version:  |a Hochfeld, William L.  |t Producing biomolecular substances with fermenters, bioreactors, and biomolecular synthesizers.  |d Boca Raton, FL : CRC/Taylor & Francis, 2006  |z 0849322707  |z 9780849322709  |w (DLC) 2005050643  |w (OCoLC)60776869. 
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