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|a QP532
|b .I584 1999
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|a W1
|b ME9611AT v.36 1999
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|a QD 471
|b I615 1999
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| 245 |
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|a Interrelations between free radicals and metal ions in life processes /
|c edited by Astrid Sigel and Helmut Sigel.
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| 260 |
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|a New York :
|b Marcel Dekker,
|c ©1999.
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| 300 |
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|a 1 online resource (xlvii, 797 pages) :
|b illustrations.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a volume
|b nc
|2 rdacarrier
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| 490 |
1 |
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|a Metal ions in biological systems ;
|v v. 36
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| 504 |
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|a Includes bibliographical references and index.
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|a Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- PREFACE TO THE SERIES -- PREFACE TO VOLUME 36 -- CONTRIBUTORS -- CONTENTS OF PREVIOUS VOLUMES -- HANDBOOK ON TOXICITY OF INORGANIC COMPOUNDS -- HANDBOOK ON METALS IN CLINICAL AND ANALYTICAL CHEMISTRY -- Chapter 1: THE MECHANISM OF "FENTON-LIKE" REACTIONS AND THEIR IMPORTANCE FOR BIOLOGICAL SYSTEMS. A BIOLOGIST'S VIEW -- 1. Introduction -- 2. The Fenton Reaction and Fenton-Like Reactions -- 3. Significance of the Fenton-Like Reactions in vivo -- 4. Conclusions -- Acknowledgments -- Abbreviations -- References -- Chapter 2: REACTIONS OF ALIPHATIC CARBON-CENTERED AND ALIPHATIC-PEROXYL RADICALS WITH TRANSITION METAL COMPLEXES AS A PLAUSIBLE SOURCE FOR BIOLOGICAL DAMAGE INDUCED BY RADICAL PROCESSES -- 1. Introduction -- 2. Sources of Radicals in Biological Systems -- 3. Redox Properties of Alkyl and Alkyl-Peroxyl Radicals -- 4. The Role of Transition Metal Complexes in Radical-Induced Biological Deleterious Processes -- 5. The "Site-Specific" Mechanism -- 6. Reactions of Aliphatic Carbon-Centered Radicals with Transition Metal Complexes in Aqueous Solutions -- 7. Mechanisms of Decomposition of the Transient Complexes, LmMn+l-R -- 8. Reactions of Alkyl-Peroxyl Radicals with Transition Metal Complexes in Aqueous Solution -- 9. Mechanisms of Decomposition of the Transient Complexes, LmMn+ l-OOR -- 10. Concluding Remarks -- Acknowledgments -- References -- Chapter 3: FREE RADICALS AS A RESULT OF DIOXYGEN METABOLISM -- 1. Introduction -- 2. Redox Chemistry, Acid-Base Chemistry and Bond Energies of Dioxygen and Reactive Oxygen Species -- 3. Major Radical Reactions of Dioxygen and Reactive Oxygen Species -- 4. Lipid Peroxidation, an Especially Facile and Major Type of Radical Chain Autoxidation -- 5. Lipid Hydroperoxides as a Major Source of Radicals.
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|a 6. Production of Reactive Oxygen Species by Respiratory Burst of Phagocytes -- 7. Conclusions -- Acknowledgments -- Abbreviations -- References -- Chapter 4: FREE RADICALS AS A SOURCE OF UNCOMMON OXIDATION STATES OF TRANSITION METALS -- 1. Introduction -- 2. Properties of Free Radicals -- 3. Generation of Free Radicals -- 4. Measurement of Reaction Rates -- 5. Interaction of Free Radicals with Simple Transition Metal Ions -- 6. Interaction of Free Radicals with Complexed Transition Metal Ions -- 7. Conclusions -- Abbreviations -- References -- Chapter 5: BIOLOGICAL CHEMISTRY OF COPPER-ZINC SUPEROXIDE DISMUTASE AND ITS LINK TO AMYOTROPHIC LATERAL SCLEROSIS -- 1. Introduction -- 2. Biophysical Properties of Wild-Type Superoxide Dismutase -- 3. Enzymatic Activity -- 4. Evidence Concerning Biological Function -- 5. Role of Mutant Human CuZn Superoxide Dismutase in Amyotrophic Lateral Sclerosis -- Acknowledgments -- Abbreviations -- References -- Chapter 6: DNA DAMAGE MEDIATED BY METAL IONS WITH SPECIAL REFERENCE TO COPPER AND IRON -- 1. Introduction -- 2. Binding of Metal Ions to DNA -- 3. DNA Lesions -- 4. Biological Implications of Metal-DNA Damage -- 5. Conclusion -- Abbreviations -- References -- Chapter 7: RADICAL MIGRATION THROUGH THE DNA HELIX: CHEMISTRY AT A DISTANCE -- 1. Introduction -- 2. Charge Transport in DNA: Chemical and Biological History -- 3. DNA as a Bridge for Long-Range Charge Transport -- 4. DNA as a Reactant in Long-Range Charge Transfer Reactions -- 5. Conclusions -- Acknowledgments -- Abbreviations -- References -- Chapter 8: INVOLVEMENT OF METAL IONS IN LIPID PEROXIDATION: BIOLOGICAL IMPLICATIONS -- 1. Introduction -- 2. Outline of the Mechanism of Lipid Peroxidation -- 3. Involvement of Metal Ions in Various Stages of the Lipid Peroxidation Process -- 4. Biological Examinations of the Effect of Metal Ions on Lipid Peroxidation.
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|a 3. Thiyl Radicals in the Presence of Iron, Cobalt, Nickel, Manganese, Chromium, and Vanadium -- 4. Copper(I)-Stabilized Thiyl Radicals -- 5. Improved Stabilization of Copper(I)-Thiyl Radicals Embedded in Inorganic and Biological Matrices -- Acknowledgments -- Abbreviations -- References -- Chapter 13: METHYLMERCURY-INDUCED GENERATION OF FREE RADICALS: BIOLOGICAL IMPLICATIONS -- 1. Introduction: The Toxicity and Pathology of Mercury -- 2. Mercury Chemistry -- 3. Mercurial-Induced Oxidative Stress in Biological Systems -- 4. Protective Mechanisms Against Mercury Toxicity -- 5. Biological Implications -- 6. Conclusions -- Acknowledgments -- Abbreviations -- References -- Chapter 14: ROLE OF FREE RADICALS IN METAL-INDUCED CARCINOGENESIS -- 1. Introduction -- 2. The Role of Free Radicals in Chromium Carcinogenesis -- 3. The Role of Free Radicals in Nickel Carcinogenesis -- 4. The Possible Role of Free Radicals in Arsenic Carcinogenesis -- 5. Beryllium Pulmonary Fibrosis and Carcinogenesis: Is There a Role for Free Radicals? -- 6. Iron and Free Radicals: Is There a Role in Carcinogenesis or Tumor Promotion? -- 7. Copper and Free Radicals: Is There a Role in Carcinogenesis? -- 8. Conclusions -- Acknowledgments -- Abbreviations -- References -- Chapter 15: pH-DEPENDENT ORGANOCOBALT SOURCES FOR ACTIVE RADICAL SPECIES: A NEW TYPE OF ANTICANCER AGENTS -- 1. Introduction: Prerequisites for the Search for Potential Anticancer Drugs Among Organocobalt Complexes -- 2. Alkylcobalt(III) Chelates with Tridentate Schiff Bases -- 3. Biomedical Examinations -- 4. Conclusion and Outlook -- Acknowledgments -- Abbreviations -- References -- Chapter 16: DETECTION OF CHROMATIN-ASSOCIATED HYDROXYL RADICALS GENERATED BY DNA-BOUND METAL COMPOUNDS AND ANTITUMOR ANTIBIOTICS -- 1. Introduction -- 2. Chromatin-Associated Hydroxyl Radicals.
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|a 3. Detection of Chromatin-Associated Hydroxyl Radicals -- 4. Methods for Attaching SECCA to In Vitro Chromatin Models -- 5. Metal Compounds and Antitumor Antibiotics that Generate Chromatin-Associated HO -- 6. Conclusions -- Acknowledgments -- Abbreviations -- References -- Chapter 17: NITRIC OXIDE (NO): FORMATION AND BIOLOGICAL ROLES IN MAMMALIAN SYSTEMS -- 1. Introduction -- 2. Biologically Relevant Chemistry of Nitric Oxide -- 3. Nitric Oxide Biosynthesis -- 4. Physiology and Pathophysiology of Nitric Oxide: A Chemical Perspective -- 5. Conclusions -- Abbreviations -- References -- Chapter 18: CHEMISTRY OF PEROXYNITRITE AND ITS RELEVANCE TO BIOLOGICAL SYSTEMS -- 1. Introduction and Brief Historical Overview -- 2. Is Peroxynitrite Formed in vivo? -- 3. Syntheses -- 4. Properties, Isomerization, and Decomposition -- 5. Reactions that Are First Order in Peroxynitrous Acid -- 6. Biomolecular Reactions -- 7. Superoxide Dismutase and Peroxynitrite -- 8. Peroxynitrite or Hydroxyl Radical? -- Note Added in Proof -- Acknowledgments -- References -- Chapter 19: NOVEL NITRIC OXIDE-LIBERATING HEME PROTEINS FROM THE SALIVA OF BLOODSUCKING INSECTS -- 1. Introduction -- 2. Strategies Used by Bloodsucking Insects to Ensure that They Obtain a Sufficient Blood Meal -- 3. Properties of Nitric Oxide -- 4. Spectroscopy of the Nitrophorins of Rhodnius prolixus in Comparison to Other Heme Proteins -- 5. Redox Chemistry of Nitric Oxide-Heme Systems and the Nitrophorins of Rhodnius prolixus -- 6. X-Ray Crystallography -- 7. Other Metal-Nitric Oxide Complexes of Importance in Inorganic Chemistry and Biochemistry -- 8. Summary -- Acknowledgments -- Abbreviations -- References -- Chapter 20: NITROGEN MONOXIDE-RELATED DISEASE AND NITROGEN MONOXIDE SCAVENGERS AS POTENTIAL DRUGS -- 1. Introduction -- 2. Nitric Oxide and Disease -- 3. Therapeutic Strategies.
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| 650 |
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|a Free radicals (Chemistry)
|x Pathophysiology.
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| 650 |
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|a Organometallic compounds
|x Pathophysiology.
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| 650 |
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|a Metal ions
|x Pathophysiology.
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| 650 |
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7 |
|a Free radicals (Chemistry)
|x Pathophysiology
|2 fast
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| 700 |
1 |
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|a Sigel, Astrid.
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| 700 |
1 |
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|a Sigel, Helmut.
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| 758 |
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|i has work:
|a Interrelations between free radicals and metal ions in life processes (Text)
|1 https://id.oclc.org/worldcat/entity/E39PD3xqT6JKp6k7XVyc8XwJgq
|4 https://id.oclc.org/worldcat/ontology/hasWork
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|w (OCoLC)40762795
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| 830 |
|
0 |
|a Metal ions in biological systems ;
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|a QP532.M47 vol. 36RB107.
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