The handbook of polyhydroxyalkanoates. Volume 1, Microbial biosynthesis and feedstocks / edited by Martin Koller.

The first volume of the "Handbook of Polyhydroxyalkanoates (PHA): Microbial Biosynthesis and Feedstocks" focusses on feedstock aspects, enzymology, metabolism and genetic engineering of PHA biosynthesis. It addresses better understanding the mechanisms of PHA biosynthesis in scientific ter...

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Bibliographic Details
Online Access:	Full Text (via Taylor & Francis)
Other Authors:	Koller, Martin (Researcher) (Editor)
Other title:	Microbial biosynthesis and feedstocks.
Format:	eBook
Language:	English
Published:	Boca Raton : CRC Press, 2020.
Subjects:	Poly-beta-hydroxyalkanoates.

Table of Contents:

Chapter 1: Monomer-Supplying Enzymes for Polyhydroxyalkanoate Biosynthesis 1.1 Introduction 1.2 PHA Biosynthesis Pathways and Related Enzymes 1.3 Monomer-Supplying Enzymes 1.4 Monomer-Supplying Pathways and Enzymes Involved 1.5 Conclusions and Outlook ReferencesChapter 2: PHA Granule-Associated Proteins and their Diverse Functions 2.1 Introduction 2.2 Granule Assembly Models 2.3 GAPs with Enzymatic Activity: PHA Synthases and Depolymerases 2.4 Non-Enzymatic GAPs: Transcriptional Regulators and Phasins 2.5 Functional Diversity of Phasins 2.6 What Makes a Phasin a Phasin? 2.7 Biotechnological Applications of GAPs 2.8 Conclusions and Outlook ReferencesChapter 3: Genomics of PHA Synthesizing Bacteria 3.1 Introduction 3.2 Short-Chain-Length PHA (scl-PHA) Producing Bacteria 3.3 Medium-Chain-Length PHA (mcl-PHA) Producing Bacteria 3.4 Scl-co-mcl-Copolymer Producers 3.5 Genomics of mcl-PHA Producing Bacteria 3.6 The Genomics of mcl-PHA Metabolism 3.7 Mcl-PHA Synthesis from Vegetable Oils and Fats 3.8 Genome Analysis of Halomonas Species 3.9 Genome Analysis of Paracoccus Species 3.10 The PHA Production Machinery in Pseudomonas putida, Cupriavidus necator, Halomonas spp. and Paracoccus spp. 3.11 Domain Organization and Structural Comparison of PhaC from Cupriavidus necator, Halomonas lutea and Paracoccus denitrificans ReferencesChapter 4: Molecular Basis of Medium-Chain Length-PHA Metabolism of Pseudomonas putida 4.1 Pseudomonas putida, a Model Bacterium for the Production of Medium-Chain-Length PHA 4.2 The PHA Cycle and its Key Proteins 4.3 Metabolic Pathways Involved in mcl-PHA Production in P. putida 4.4 PHA Metabolism Regulation 4.5 Conclusions and Outlook ReferencesChapter 5: Production of Polyhydroxyalkanoates by Paraburkholderia and Burkholderia species: A Journey from the Genes through Metabolic Routes to their Biotechnological Applications 5.1 Introduction 5.2 PHA Synthases 5.3 Genomic Analysis of pha Genes on Paraburkholderia and Burkholderia Species 5.4 Metabolic Routes of PHA Synthesis 5.5 PHA Production from Low-Cost Substrates 5.6 Properties of PHA Synthesized by Paraburkholderia and Burkholderia Species 5.7 Biomedical and Biotechnological Applications ReferencesChapter 6: Genetic Engineering as a Tool for Enhanced PHA Biosynthesis from Inexpensive Substrates 6.1 Introduction 6.2 Engineering Techniques Applied to Obtain Recombinant Strains for PHA Production 6.3 The Use of Whey as Carbon Source 6.4 The Use of Molasses as Carbon Source 6.5 The Use of Lipids as Carbon Source 6.6 The Use of Starchy Materials as Carbon Source 6.7 The Use of Lignocellulosic Materials as Carbon Source 6.8 Conclusions and Outlook ReferencesChapter 7: Biosynthesis and Sequence Control of scl-PHA and mcl-PHA 7.1 Introduction 7.2 The Key Factors of PHA Biosynthesis 7.3 Sequence Control of scl-PHA and mcl-PHA References Chapters 8-15: FeedstocksChapter 8: Inexpensive and Waste Raw Materials for PHA Production 8.1 Introduction 8.2 Oleaginous lipid-based feedstocks 8.3 Mixed Organic Acid Feedstocks 8.4 Mono- and Polysaccharide Feedstocks 8.5 Carbon Dioxide as a Feedstock 8.6 Other Carbon Feedstocks 8.7 Conclusions and Outlook ReferencesChapter 9: Sustainable Production of Polyhydroxyalkanoates from Crude Glycerol 9.1 Introduction
Polyhydroxyalkanoates (PHA) 9.2 Crude Glycerol from Biodiesel Manufacture 9.3 Metabolic Pathways of PHA Synthesis from Glycerol 9.4 Production of PHA from Crude Glycerol 9.5 Characterization of PHA Synthesized from Glycerol 9.6 Metabolic Engineering for Glycerol-Based PHA Production 9.7 Impact of Crude Glycerol on the Molecular Mass of PHA 9.8 Conclusions and Outlook ReferencesChapter 10: Biosynthesis of Polyhydroxyalkanoates (PHA) from Vegetable Oils and its By-products by Wild-Type and Recombinant Microbes 10.1 Introduction 10.2 Biosynthesis of PHA from Plant Oils 10.3 Challenges in Using Different Types of Microorganisms in Large Scale PHA Production 10.4 Application of Waste Vegetable Oils and Non-Food Grade Plant Oils for Large Scale Production of PHA 10.5 Conclusions and Outlook ReferencesChapter 11: Production and Modification of PHA Polymers Produced from Long-Chain Fatty Acid 11.1 Introduction 11.2 Strategies for Production of mcl-PHA 11.3 Strategies for Maximum Volumetric Productivity 11.4 Strategies for Improved Substrate Yields from MCFAs and LCFAs 11.5 Extracellular Lipase for Triacylglyceride Consumption 11.6 Biosynthesis and Monomer Composition 11.7 Functional Modifications of mcl-PHA 11.8 Cross-Linking 11.9 Conclusions and Outlook ReferencesChapter 12: Converting Petrochemical Plastic to Biodegradable Plastic 12.1 Introduction: The Plastic Waste Issue 12.2 Strategies for Up-Cycling of Plastic Waste 12.3 Enzymatic Degradation of Petrochemical Plastics 12.4 Metabolism of Plastics' Monomers and the Connection with PHA 12.5 Conclusions and Outlook ReferencesChapter 13: Comparing Heterotrophic with Phototrophic PHA Production
Concurring or Complementing Strategies? 13.1 Introduction
The Status Quo of PHB Production 13.2 Heterotrophic PHA Production for Comparison 13.3 PHB Synthesis in Cyanobacteria 13.4 Light as Energy Source for Cyanobacteria 13.5 CO2 as a Carbon Source for Cyanobacteria 13.6 Nutrients for Cyanobacterial Growth 13.7 Other Growth Conditions for Cyanobacteria 13.8 Current Status of Phototrophic PHA Production 13.9 Phototrophic Cultivation Systems 13.10 Recombinant Cyanobacteria for PHA Production 13.11 PHA Isolation from the Cells, Purification and Resulting Qualities 13.12 Utilisation of Residual Cyanobacteria Biomass 13.13 Comparing Heterotrophically with Phototrophically Produced PHB 13.14 Conclusions and Outlook ReferencesChapter 14: Coupling Biogas (CH4) with PHA Biosynthesis 14.1 Introduction 14.2 Biogas Market 14.3 Methanotrophs 14.4 PHA Biosynthesis from Methane 14.5 Genome Scale Metabolic Models as a Tool for Understanding the Metabolism of PHB in Methanotrophs 14.6 Bioreactors for Biogas Bioconversion 14.7 Techno-Economic Analysis of PHA Production from Biogas ReferencesChapter 15: Syngas as a Sustainable Carbon Source for PHA Production 15.1 Introduction 15.2 Syngas 15.3 Production of Syngas from Organic Waste and Biomass 15.4 Concept of Bacterial PHA Synthesis from Syngas 15.5 Production of PHA by Acetogens Based on Syngas as Substrate 15.6 PHA Production by Rhodospirillum rubrum Grown on Syngas 15.7 Synthesis of PHA by Carboxydobacteria Grown on Syngas 15.8 PHA Production by CO-Tolerant Hydrogen-Oxidizing Strains on Syngas 15.9 Bioprocesses for PHA Production on Syngas 15.10 Conclusions and Outlook References

The handbook of polyhydroxyalkanoates. Volume 1, Microbial biosynthesis and feedstocks / edited by Martin Koller.

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