Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide ?-amyloid (1?42) [electronic resource]
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Full Text (via OSTI) |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Department of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
2014.
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| Abstract: | For decades, a link between increased levels of iron and areas of Alzheimer?sdisease (AD) pathology has been recognized, including AD lesions comprisedof the peptide b-amyloid (Ab). Despite many observations of this association,the relationship between Ab and iron is poorly understood. Using X-raymicrospectroscopy, X-ray absorption spectroscopy, electron microscopy andspectrophotometric iron(II) quantification techniques, we examine the interaction between Ab(1?42) and synthetic iron(III), reminiscent of ferric ironstores in the brain. We report Ab to be capable of accumulating iron(III)within amyloid aggregates, with this process resulting in Ab-mediatedreduction of iron(III) to a redox-active iron(II) phase. Additionally, we showthat the presence of aluminium increases the reductive capacity of Ab,enabling the redox cycling of the iron. These results demonstrate the abilityof Ab to accumulate iron, offering an explanation for previously observedlocal increases in iron concentration associated with AD lesions. Furthermore,the ability of iron to form redox-active iron phases from ferric precursorsprovides an origin both for the redox-active iron previously witnessed inAD tissue, and the increased levels of oxidative stress characteristic ofAD. These interactions between Ab and iron deliver valuable insights intothe process of AD progression, which may ultimately provide targets fordisease therapies. |
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| Item Description: | Published through Scitech Connect. 06/06/2014. "Journal ID: ISSN 1742-5689." Everett, J. ; Cšpedes, E. ; Shelford, L. R. ; Exley, C. ; Collingwood, J. F. ; Dobson, J. ; van der Laan, G. ; Jenkins, C. A. ; Arenholz, E. ; Telling, N. D. ; et al; |
| Physical Description: | Size: Article No. 20140165 : digital, PDF file. |