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|a Mitochondrial replacement techniques :
|b ethical, social, and policy considerations /
|c Anne Claiborne, Rebecca English, Jeffrey Kahn, editors ; Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases, Board on Health Sciences Policy, Institute of Medicine, National Academies of Sciences, Engineering, and Medicine.
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| 264 |
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1 |
|a Washington, D.C. :
|b National Academies Press,
|c [2016]
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| 300 |
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|a 1 online resource (1 PDF file (xvi, 184 pages)) :
|b illustrations.
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|b txt
|2 rdacontent.
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|a computer
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|a online resource
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|a Includes bibliographical references.
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0 |
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|a Introduction -- Science and policy context -- Do ethical, social, and policy considerations preclude MRT? -- Regulation and oversight of MRT in humans.
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3 |
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|a Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.
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| 546 |
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|a English.
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| 588 |
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|a Online resource; title from PDF title page (viewed May 27, 2016)
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|a This activity was supported by Contract No. HHSP233201400020B/HHSP2337010 between the National Academy of Sciences and the U.S. Department of Health and Human Services, U.S. Food and Drug Administration. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.
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| 650 |
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0 |
|a Reproductive technology
|x Moral and ethical aspects
|z United States.
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| 650 |
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0 |
|a Reproductive technology
|x Government policy
|z United States.
|
| 650 |
|
0 |
|a Mitochondrial DNA
|x Abnormalities
|z United States.
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| 650 |
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0 |
|a Mitochondrial pathology
|z United States.
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| 650 |
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0 |
|a Medical ethics
|z United States.
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| 650 |
|
7 |
|a Medical ethics.
|2 fast
|0 (OCoLC)fst01014081.
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| 650 |
|
7 |
|a Mitochondrial DNA
|x Abnormalities.
|2 fast
|0 (OCoLC)fst01024019.
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| 650 |
|
7 |
|a Mitochondrial pathology.
|2 fast
|0 (OCoLC)fst01024022.
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| 650 |
|
7 |
|a Reproductive technology
|x Moral and ethical aspects.
|2 fast
|0 (OCoLC)fst01095010.
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| 651 |
|
7 |
|a United States.
|2 fast
|0 (OCoLC)fst01204155.
|
| 700 |
1 |
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|a Claiborne, Anne B.,
|e editor.
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| 700 |
1 |
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|a English, Rebecca A.,
|e editor.
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| 700 |
1 |
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|a Kahn, Jeffrey P.,
|e editor.
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| 710 |
2 |
|
|a Institute of Medicine (U.S.).
|b Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases,
|e issuing body.
|
| 776 |
0 |
8 |
|i Print version:
|t Mitochondrial replacement techniques.
|d Washington, D.C. : National Academies Press, 2016
|z 9780309388702
|w (OCoLC)933521007.
|
| 856 |
4 |
0 |
|u https://ebookcentral.proquest.com/lib/ucb/detail.action?docID=4455148
|z Full Text (via ProQuest)
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| 907 |
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|a .b118806269
|b 05-09-22
|c 06-28-21
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