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|a Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart
|h [electronic resource] :
|b Degenerative Disease Risks.
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|a Washington, D.C. :
|b United States. Department of Energy. Office of Science ;
|a Oak Ridge, Tenn. :
|b Distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
|c 2021.
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| 300 |
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|a Size: Article No. 387 :
|b digital, PDF file.
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|a text
|b txt
|2 rdacontent.
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|2 rdamedia.
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|a online resource
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|a Published through Scitech Connect.
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|a 02/13/2021.
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|a "Journal ID: ISSN 2073-4409."
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|a ": US2212813."
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|a Garikipati, Venkata Srikanth ; Arakelyan, Arsen ; Blakely, Eleanor A. ; Chang, Polly Y. ; Truongcao, May M. ; Cimini, Maria ; Malaredy, Vandana ; Bajpai, Anamika ; Addya, Sankar ; Bisserier, Malik ; et al.
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|a <jats:p>Compared to low doses of gamma irradiation (?-IR), high-charge-and-energy (HZE) particle IR may have different biological response thresholds in cardiac tissue at lower doses, and these effects may be IR type and dose dependent. Three- to four-month-old female CB6F1/Hsd mice were exposed once to one of four different doses of the following types of radiation: ?-IR 137Cs (40-160 cGy, 0.662 MeV), 14Si-IR (4-32 cGy, 260 MeV/n), or 22Ti-IR (3-26 cGy, 1 GeV/n). At 16 months post-exposure, animals were sacrificed and hearts were harvested and archived as part of the NASA Space Radiation Tissue Sharing Forum. These heart tissue samples were used in our study for RNA isolation and microarray hybridization. Functional annotation of twofold up/down differentially expressed genes (DEGs) and bioinformatics analyses revealed the following: (i) there were no clear lower IR thresholds for HZE- or ?-IR; (ii) there were 12 common DEGs across all 3 IR types; (iii) these 12 overlapping genes predicted various degrees of cardiovascular, pulmonary, and metabolic diseases, cancer, and aging; and (iv) these 12 genes revealed an exclusive non-linear DEG pattern in 14Si- and 22Ti-IR-exposed hearts, whereas two-thirds of ?-IR-exposed hearts revealed a linear pattern of DEGs. Thus, our study may provide experimental evidence of excess relative risk (ERR) quantification of low/very low doses of full-body space-type IR-associated degenerative disease development.</jats:p>
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|a 63 radiation, thermal, and other environ. pollutant effects on living orgs. and biol. mat.
|2 local.
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|a Radiation, thermal, and other environ. pollutant effects on living orgs. and biol. mat.
|2 local.
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|a Lawrence Berkeley National Laboratory.
|4 res.
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|a United States.
|b Department of Energy.
|b Office of Science.
|4 spn.
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information
|4 dst.
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|u https://www.osti.gov/servlets/purl/1807569
|z Full Text (via OSTI)
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|a .b119023830
|b 02-28-23
|c 07-26-21
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|a University of Colorado Boulder
|b Online
|c Online
|d Online
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