Enzyme systems that metabolise drugs and other xenobiotics [electronic resource] / edited by Costas Ioannides.
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically...
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| Online Access: |
Full Text (via Wiley) |
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| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Chichester ; New York :
J. Wiley,
©2002.
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| Series: | Current toxicology series.
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| Subjects: |
| Summary: | This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:*enzyme function in the metabolism and bioactivation of xenobiotics*substrate specificity*tissue distribution*species distribution (to include laboratory animals and humans)*hormonal regulation*sex differences*modulation by prior exposure to other chemicals*age-dependent expression*pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists. |
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| Physical Description: | 1 online resource (viii, 578 pages) : illustrations. |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 0470851988 9780470851982 0470846305 9780470846308 0471894664 9780471894667 128065435X 9781280654350 9786610654352 6610654352 |
| Language: | English. |
| Source of Description, Etc. Note: | Print version record. |