Enzyme systems that metabolise drugs and other xenobiotics [electronic resource] / edited by Costas Ioannides.
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically...
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Full Text (via Wiley) |
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| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Chichester ; New York :
J. Wiley,
©2002.
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| Series: | Current toxicology series.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Enzyme systems that metabolise drugs and other xenobiotics |h [electronic resource] / |c edited by Costas Ioannides. |
| 260 | |a Chichester ; |a New York : |b J. Wiley, |c ©2002. | ||
| 300 | |a 1 online resource (viii, 578 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
| 338 | |a online resource |b cr |2 rdacarrier. | ||
| 490 | 1 | |a Current toxicology series. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Cover -- Contents -- Contributors -- Foreword -- 1 Xenobiotic Metabolism58; An Overview -- 2 Cytochrome P450 -- 3 Flavin Monooxygenases -- 4 Amine Oxidases and the Metabolism of Xenobiotics -- 5 Molybdenum Hydroxylases -- 6 Prostaglandin Synthases -- 7 Lipoxygenases -- 8 UDP45;Glucuronosyltransferases -- 9 Glutathione S45;transferases -- 10 Sulphotransferases -- 11 Arylamine Acetyltransferases -- 12 Mammalian Xenobiotic Epoxide Hydrolases -- 13 Methyltransferases -- 14 The Amino Acid Conjugations -- 15 Deconjugating Enzymes58; Sulphatases and Glucuronidases -- 16 Nitroreductases and Azoreductases -- Index -- Last Page. | |
| 520 | |a This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:*enzyme function in the metabolism and bioactivation of xenobiotics*substrate specificity*tissue distribution*species distribution (to include laboratory animals and humans)*hormonal regulation*sex differences*modulation by prior exposure to other chemicals*age-dependent expression*pharmacogenetics and modulation by disease. Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists. | ||
| 546 | |a English. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Drugs |x Metabolism. |0 http://id.loc.gov/authorities/subjects/sh85039737. | |
| 650 | 0 | |a Xenobiotics |x Metabolism. |0 http://id.loc.gov/authorities/subjects/sh2008124341. | |
| 650 | 0 | |a Enzymes |x Mechanism of action. | |
| 650 | 7 | |a Drugs |x Metabolism. |2 fast |0 (OCoLC)fst00898845. | |
| 650 | 7 | |a Xenobiotics |x Metabolism. |2 fast |0 (OCoLC)fst01181975. | |
| 700 | 1 | |a Ioannides, Costas. |0 http://id.loc.gov/authorities/names/n79071809 |1 http://isni.org/isni/000000012385017X. | |
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| 830 | 0 | |a Current toxicology series. |0 http://id.loc.gov/authorities/names/n98039092. | |
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