Successful drug discovery / edited by János Fischer and David P. Rotella.
The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds:small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very...
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Full Text (via Wiley) |
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| Format: | eBook |
| Language: | English |
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Weinheim, Germany :
Wiley-VCH,
2015.
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Table of Contents:
- Part I: General Aspects. Serendipitous Target-Based Drug Discoveries / János Fischer, David P Rotella
- Drug Discoveries and Molecular Mechanism of Action / David C Swinney
- Part II: Drug Class. Insulin Analogs
- Improving the Therapy of Diabetes / John M Beals
- Part III: Case Histories. The Discovery of Stendra (Avanafil) for the Treatment of Erectile Dysfunction / Koichiro Yamada, Toshiaki Sakamoto, Kenji Omori, Kohei Kikkawa
- Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes / William N Washburn
- Elvitegravir, A New HIV-1 Integrase Inhibitor for Antiretroviral Therapy / Hisashi Shinkai
- Discovery of Linagliptin for the Treatment of Type 2 Diabetes Mellitus / Matthias Eckhardt, Thomas Klein, Herbert Nar, Sandra Thiemann
- The Discovery of Alimta (Pemetrexed) / Edward C Taylor
- Perampanel: A Novel, Noncompetitive AMPA Receptor Antagonist for the Treatment of Epilepsy / Shigeki Hibi
- Discovery and Development of Telaprevir (Incivek): A Protease Inhibitor to Treat Hepatitis C Infection / Bhisetti G Rao, Mark Murcko, Mark J Tebbe, Ann D Kwong
- Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1) / Sandhya Girish, Gail D Lewis Phillips, Fredric S Jacobson, Jagath R Junutula, Ellie Guardino.