Validation of the TOPAS Monte Carlo toolkit for HDR brachytherapy simulations [electronic resource]
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| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Department of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
2021.
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| Abstract: | The goal of this work is to validate the user-friendly Geant4-based Monte Carlo toolkit TOol for PArticle Simulation (TOPAS) for brachytherapy applications. Brachytherapy simulations performed with TOPAS were systematically compared with published TG-186 reference data. The photon emission energy spectrum, the air-kerma strength, and the dose-rate constant of the model-based dose calculation algorithm (MBDCA)-WG generic Ir-192 source were extracted. For dose calculations, a track-length estimator was implemented. Additionally, the four Joint AAPM/ESTRO/ABG MBDCA-WG test cases were evaluated through histograms of the local and global dose difference volumes. A prostate, a palliative lung, and a breast case were simulated. For each case, the dose ratio map, the histogram of the global dose difference volume, and cumulative dose-volume histograms were calculated. The air-kerma strength was (9.772 ł 0.001) × 10<sup>-8</sup> U Bq<sup>-1</sup> (within 0.3% of the reference value). The dose-rate constant was 1.1107 ł 0.0005 cGy h<sup>-1</sup> U<sup>-1</sup> (within 0.01% of the reference value). For all cases, at least 96.9% of voxels had a local dose difference within [-1%, 1%] and at least 99.9% of voxels had a global dose difference within [-0.1%, 0.1%]. The implemented track-length estimator scorer was more efficient than the default analog dose scorer by a factor of 237. For all clinical cases, at least 97.5% of voxels had a global dose difference within [-1%, 1%]. Dose-volume histograms were consistent with the reference data. TOPAS was validated for high-dose-rate brachytherapy simulations following the TG-186 recommended approach for MBDCAs. Built on top of Geant4, TOPAS provides broad access to a state-of-the-art Monte Carlo code for brachytherapy simulations. |
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| Item Description: | Published through Scitech Connect. 04/23/2021. "Journal ID: ISSN 1538-4721." "Other: RGPIN-2019-05038." "U24 CA215123." "RGPIN-2019-05038." Berumen, Francisco ; Ma, Yunzhi ; Ramos-Mňdez, Jos ̌; Perl, Joseph ; Beaulieu, Luc ; SLAC National Accelerator Lab., Menlo Park, CA (United States) Natural Sciences and Engineering Research Council of Canada (NSERC) |
| Physical Description: | Size: p. 911-921 : digital, PDF file. |