Neuroinflammation / edited by Alireza Minagar.
Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comp...
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| Online Access: |
Full Text (via ProQuest) |
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
London :
Academic Press, an imprint of Elsevier,
[2018]
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| Edition: | Second edition. |
| Subjects: |
Table of Contents:
- Front Cover; Neuroinflammation; Copyright Page; Contents; List of Contributors; Preface; 1 Multiple Sclerosis: Clinical Features, Pathophysiology, Diagnosis, and Management; Clinical Features; Initial Presentation of MS; Clinical Course of MS; MS-Exacerbating Conditions; Pathophysiology; Pathophysiology of Relapses and Disease Progression; "Inflammation" in MS Pathophysiology; "Degeneration" in MS Pathophysiology; Inflammation-Induced Degenerative Processes; Primary Degenerative Processes; Pathophysiology of Remissions; Pathophysiology of Cortical Manifestations; Diagnosis; Management.
- NAb Titer and Defining NAb StatusClinical Relevance of NAbs; Clinical Outcomes; MRI Outcomes; NAbs Testing in Clinical Practice; Glatiramer Acetate; Natalizumab; Conclusion; References; 3 Animal Models of Multiple Sclerosis; Etiology, Clinical Course, and Pathology; Etiologies of MS and Its Animal Models; Animal Models: EAE and TMEV Infection; Clinical Courses of MS and Its Animal Models; Pathology of MS and Its Animal Models; Demyelination Versus Axonal Degeneration (Neurodegeneration): Inside-Out Model of MS; CD4+ T-cells in MS and Its Animal Models; Th Cell Subsets.
- Roles of Th1 Cells in EAE and TMEV InfectionRoles of Th2 Cells in EAE and TMEV Infection; Roles of Th17 Cells in EAE and TMEV Infection; Roles of Tregs in EAE and TMEV Infection; Chemokines and Chemokine Receptors in MS and Its Animal Models; Chemokines and Chemokine Receptors; CXCR3 and Its Ligands in MS, EAE, and TMEV Infection; CCR5 and Its Ligands in MS, EAE, and TMEV Infection; CCR2 and Its Ligands in MS, EAE, and TMEV Infection; CCR4 and Its Ligands in MS and EAE; CCR6 and Its Ligands in MS and EAE; Future Perspectives.
- MS Heterogeneities Explain the Differing Roles of Th Cell Subsets and Chemokine ReceptorsChemokines and Chemokine Receptors as a Potential Target for MS Treatment; Acknowledgments; References; 4 Neuroimaging of Multiple Sclerosis and Other Immune-Mediated Diseases of Central Nervous System: An Update; Introduction; Imaging of Multiple Sclerosis; Conventional Imaging; Imaging Findings; Nonconventional Imaging Techniques in the Differential Diagnosis of MS; Susceptibility-Weighted Imaging; Perfusion Imaging; MR Spectroscopy; Diffusion Tensor Imaging; Radiologically Isolated Syndrome (RIS)
- Management of Acute RelapsesDisease-Modifying Therapies; Interferon-Beta; Glatiramer Acetate; Dimethyl Fumarate; Teriflunomide; Fingolimod; Natalizumab; Alemtuzumab; Daclizumab; References; Further Reading; 2 Neutralizing Antibodies and Multiple Sclerosis in the Era of Disease Modifying Treatments; Introduction; Interferon Beta; Immunogenicity; Neutralizing Antibody Assays; The Cytopathic Effect (CPE) Assay; Assays Based on the Interferon-β-Stimulated Production of Myxovirus Resistance Protein A; The Reporter Gene Assay; The In Vivo Induction of Myxovirus Resistance Protein A.