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|b .S564 2023
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|a Singh, Vijai,
|e author.
|0 http://id.loc.gov/authorities/names/no2020070045
|1 http://isni.org/isni/0000000449614417
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| 245 |
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|a Epigenetics in health and disease.
|n Part B. /
|c Vijai Singh and Indra Mani.
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| 264 |
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|a Cambridge, MA :
|b Academic Press,
|c [2023]
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|c ©2023
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|a 1 online resource (294 pages).
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|b txt
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|a Intro -- Epigenetics in Health and Disease -- Part B -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Applications of bioinformatics in epigenetics -- 1. Introduction -- 1.1. DNA methylation -- 1.2. Histone modification -- 1.3. Non-coding RNA (ncRNA) -- 2. Epigenetic data processing and analysis -- 2.1. Chromatin immunoprecipitation -- 2.2. Bisulfite sequencing -- 2.3. Methylated DNA immunoprecipitation (MeDIP-Seq) -- 3. Epigenetics databases -- 3.1. MethDB -- 3.2. REBASE -- 3.3. Pubmeth -- 3.4. MethPrimerDB -- 3.5. The histone database -- 3.6. ChromDB -- 3.7. MeInfo Text database -- 3.8. EpimiR -- 3.9. Methylome DB -- 3.10. dbHiMo -- 4. In silico tools for epigenetic modification -- 4.1. compEpiTools -- 4.2. CpGProD -- 4.3. MethBlAST -- 4.4. EpiExplorer -- 4.5. BiQ analyzer -- 5. Conclusion and future perspectives -- Conflict of interest -- References -- Chapter Two: CRISPR-dCas9 system for epigenetic editing towards therapeutic applications -- 1. Introduction -- 2. Approaches of epigenome modification using CRISPR-dCas9 -- 2.1. CRISPR-dCas9 system for DNA methylation or demethylation -- 2.2. CRISPR-dCas9 system for DNA acetylation -- 2.3. CRISPR-dCas9 system for DNA phosphorylation -- 3. Conclusions and future remarks -- Acknowledgments -- References -- Chapter Three: Epigenetic control of heredity -- 1. Introduction -- 2. Epigenetic inheritance -- 2.1. Intergenerational and transgenerational epigenetic inheritance -- 2.2. Molecular mechanism underlying intergenerational and transgenerational epigenetic inheritance -- 2.3. Epigenetic inheritance in model organisms -- 2.3.1. Caenorhabditis elegans -- 2.3.2. Drosophila melanogaster -- 2.3.3. Danio rerio -- 2.3.4. Mus musculus -- 3. Epigenetic control on gene expression -- 4. DNA methylation and heredity -- 4.1. DNA methyltransferases -- 4.2. Inheritance of DNA methylation.
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|a 5. Histone modifications and heredity -- 6. Non-coding RNAs and heredity -- 7. Factors influencing epigenesis, associated diseases and their inheritance -- 7.1. Environmental factors -- 7.2. Psychological and social factors -- 8. Role of epigenetic inheritance in heritability of diseases -- 9. Conclusions -- 10. Future perspective -- Acknowledgments -- Conflict of interest -- References -- Chapter Four: Epigenetics in renal diseases -- 1. Introduction -- 2. Epigenetic mechanisms in renal diseases -- 2.1. DNA methylation -- 2.2. Histone modification -- 2.3. Non-coding RNA (ncRNA) -- 3. Conclusion and future perspectives -- Conflict of interest -- References -- Chapter Five: Epigenetics in cancer development, diagnosis and therapy -- 1. Introduction -- 2. Epigenetics and cancer development -- 2.1. DNA methylations and cancer development -- 2.2. Histone modification and cancer development -- 3. Epigenetics and cancer diagnosis -- 3.1. DNA methylations and cancer diagnosis -- 3.2. Histone modification and cancer diagnosis -- 4. Epigenetics and cancer therapy -- 4.1. DNA methylations and cancer therapy -- 4.2. Histone modification and cancer therapy -- 5. Conclusion and future direction -- Acknowledgments -- References -- Chapter Six: Microbiota and epigenetics: Health impact -- 1. Introduction -- 2. Epigenetic processes -- 3. Interaction among diet, microbiome, and epigenetics -- 4. Epigenetics and microbiome in the diseased states -- 5. Therapeutic approaches -- 6. Conclusion -- 7. Future perspective -- References -- Chapter Seven: Histone deacetylase (HDACs) inhibitors: Clinical applications -- 1. Introduction -- 1.1. HDACi inhibitors overview -- 2. The roles of HDACs in cancer -- 2.1. Class I HDACs -- 2.2. Class IIa HDACs -- 2.3. Class IIb HDACs -- 2.4. Class III HDACs -- 2.5. SIRT1 and 2 -- 2.6. SIRT3, 4, and 5 -- 2.7. SIRT6 and 7.
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| 505 |
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|a 2.8. Class IV HDAC -- 2.9. Role of HDACi in cancer -- 2.10. Potential role of HDACi in cancer -- 2.11. Combinational therapy in cancer -- 3. HDAC inhibitors in neurodegenerative diseases -- 3.1. Parkinson´s disease -- 3.2. Alzheimer´s disease -- 3.3. Spinal muscular atrophy -- 3.4. Huntington disease -- 3.5. Multiple sclerosis -- 4. HDACi in cardiovascular diseases -- 4.1. Cardiac hypertrophy -- 4.2. Myocardial infarction and ischemia-reperfusion injury -- 4.3. Hypertension -- 4.4. Other cardiovascular diseases -- 5. Conclusions -- References -- Chapter Eight: Early epigenetic markers for precision medicine -- 1. Introduction -- 2. What is epigenetics? -- 3. Epigenetic modifications -- 4. Role of epigenetics in biological processes -- 5. Epigenetics in cancer -- 6. Epigenetic in neurological disorders -- 7. Conclusions -- References -- Chapter Nine: Epigenetics of neurological diseases -- 1. Introduction -- 2. Epigenetic layers and their regulators -- 3. Epigenetic dysregulation in neurological disorders -- 3.1. Alzheimer´s disease -- 3.2. Parkinson´s disease -- 3.3. Epilepsy -- 3.4. Huntington´s disease -- 3.5. ALS -- 3.6. Multiple sclerosis -- 4. Therapeutic potential -- 5. Conclusion -- References -- Chapter Ten: Epigenetic regulons in Alzheimer´s disease -- 1. Introduction -- 2. Epigenetic mechanisms -- 2.1. DNA methylation -- 2.2. Histone protein modifications -- 2.3. Non-coding RNAs -- 3. Environmental factors in the progression of AD -- 4. Epigenetic mechanisms in Alzheimer´s disease (AD) -- 4.1. DNA methylation in AD -- 4.2. Histone tail modification in AD -- 4.3. Non-coding RNA in AD -- 5. Epigenetic therapeutics in AD -- 6. Conclusions -- Acknowledgments -- Conflict of interest -- References -- Chapter Eleven: Epigenetics in epilepsy -- 1. Introduction -- 2. Epigenetic modifications in epilepsy -- 2.1. DNA methylation.
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| 505 |
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|a 2.2. Histone modifications -- 2.2.1. Acetylation -- 2.2.2. Methylation -- 2.2.3. Phosphorylation -- 2.2.4. Ubiquitination -- 2.3. Non-coding RNAs -- 2.4. miRNAs -- 2.4.1. Long noncoding RNAs -- 2.4.2. CircRNAs -- 2.4.3. Genes with epigenetic functions implicated in epilepsy -- 3. Therapeutic prospects -- 4. Conclusion -- References -- Index.
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|a Description based on print version record.
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| 504 |
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|a Includes bibliographical references and index.
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| 650 |
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|a Pathology, Cellular.
|0 http://id.loc.gov/authorities/subjects/sh85098687
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|a Cells
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|a Mani, Indra,
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