The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens [electronic resource] : final report / Robert D. Johnson, Russell J. Lewis, Mike K. Angier.
During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by avi...
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| Other title: | Liquid chromatography/mass spectrometry quantification of vardenafil (Levitra®) in postmortem biological specimens. |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Ft. Belvior, VA : Springfield, Va. :
Federal Aviation Administration, Office of Aerospace Medicine ; Available to the public through the Defense Technical Information Center ; Available to the public through the National Technical Information Service,
2006.
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| Subjects: |
MARC
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| 245 | 1 | 4 | |a The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens |h [electronic resource] : |b final report / |c Robert D. Johnson, Russell J. Lewis, Mike K. Angier. |
| 246 | 3 | |a Liquid chromatography/mass spectrometry quantification of vardenafil (Levitra®) in postmortem biological specimens. | |
| 264 | 1 | |a Washington, D.C. : |b Federal Aviation Administration, Office of Aerospace Medicine ; |a Ft. Belvior, VA : |b Available to the public through the Defense Technical Information Center ; |a Springfield, Va. : |b Available to the public through the National Technical Information Service, |c 2006. | |
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| 504 | |a Includes bibliographical references (page 10) | ||
| 500 | |a "DOT/FAA/AM-06/17." | ||
| 520 | |a During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens. | ||
| 538 | |a Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/27/06: http://www.faa.gov/library/reports/medical/oamtechreports/2000s/media/200617.pdf; current access via PURL. | ||
| 536 | |a Performed by FAA Civil Aerospace Medical Institute, Oklahoma City, OK, under approved task no. |g AM-B-05-TOX-204. | ||
| 650 | 0 | |a Forensic toxicology |z United States. | |
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| 700 | 1 | |a Lewis, Russell J. |0 http://id.loc.gov/authorities/names/no2001037000 |1 http://isni.org/isni/0000000040909906. | |
| 700 | 1 | |a Angier, Mike K. |0 http://id.loc.gov/authorities/names/n2006183061 |1 http://isni.org/isni/0000000040431906. | |
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| 776 | 0 | |a Johnson, Robert D. |t LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens |h i, 10 p. |w (OCoLC)71229225. | |
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