Cell cycle regulation [electronic resource] / Philipp Kaldis (ed.)

The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degrada...

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Bibliographic Details
Online Access: Full Text (via Springer)
Other Authors: Kaldis, Philipp
Format: Electronic eBook
Language:English
Published: Berlin : Springer, 2006.
Series:Results and problems in cell differentiation ; 42.
Subjects:

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490 1 |a Results and problems in cell differentiation ;  |v 42. 
504 |a Includes bibliographical references and index. 
505 0 |a G1 phase : components, conundrums, context / Stephanie J. Moeller and Robert J. Sheaff -- Regulation of S phase / Jamie K. Teer and Anindya Dutta -- Checkpoint and coordinated cellular responses to DNA damage / Xiaohong H. Yang and Lee Zou -- Protein kinases involved in mitotic spindle checkpoint regulation / Ingrid Hoffmann -- The centrosome cycle / Christopher P. Mattison and Mark Winey -- The ubiquitin-proteasome pathway in cell cycle control / Steven I. Reed -- The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis / Jan-Hermen Dannenberg and Hein P.J. te Riele -- Modeling cell cycle control and cancer with pRB tumor suppressor / Lili Yamasaki -- Senescence and cell cycle control / Hiroaki Kiyokawa -- Mouse models of cell cycle regulators : new paradigms / Eiman Aleem and Philipp Kaldis -- Control of cell proliferation and growth by Myc proteins / Sandra Bernard and Martin Eilers -- Cell cycle regulation in mammalian germ cells / Changanamkandath Rajesh and Douglas L. Pittman. 
520 |a The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degradation, DNA damage response, mitotic spindle checkpoint, the centrosome cycle, Retinoblastoma protein family, the Myc oncogene, and mouse models for tumor suppressors, cyclin-dependent kinases, and meiosis. These chapters written by experts provide an updated view on how the cell cycle is regulated in vivo and about the involvement of cell cycle regulators in cancer. 
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