The development of iodine-123-methyl-branched fatty acids and their applications in nuclear cardiology [electronic resource]
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| Online Access: |
Online Access |
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| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Dept. of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
1993.
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| Abstract: | Continued Interest in the use of iodine-1 23-labeled fatty acids for myocardial Imaging results from observations from a variety of studies that in many types of cardiac disease, regional fatty acid myocardial uptake patterns are often different than regional distribution of flow tracers. These differences may reflect alterations in important parameters of metabolism which can be useful for patient management or therapeutic strategy decision making. In addition, use of iodine-I 23-labeled fatty acid distribution may represent a unique metabolic probe to relate some aspects of the metabolism of these substrates with the regional viability of cardiac tissue. The use of such viability markers could provide important prognostic information on myocardial salvage, helping to identify patients for revascularization or angioplasty. Clinical studies are currently in progress with the iodine-123-labeled 1 5-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) fatty acid analogue at several institutions. The goals of this paper are to discuss development of the concept of metabolic trapping of fatty acids, to briefly review development and evaluation of various radioiodinated methyl-branched fatty acids and to discuss recent patient studies with iodine-123 (BMIPP) using single photon emission computerized tomography (SPECT) |
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| Item Description: | Published through the Information Bridge: DOE Scientific and Technical Information. 06/01/1993. "bnl--48712" " conf-9302119--1" "DE93014051" ": Grant CRG 900966" 3. international symposium on radioiodinated fatty acids,Kyoto (Japan),10-11 Feb 1993. Goodman, M.M.; Knapp, F.F. Jr.; Ambrose, K.R.; Kropp, J.; Biersack, H.J.; Visser, F.C.; Som, P.; Reske, S.N.; Franken, P.; Sloof, G.W. |
| Physical Description: | 45 p. : digital, PDF file. |