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|a (TOE)ost10184286
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|a (TOE)10184286
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|a E 1.99:lbl--34375
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|a lbl--34375
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|a Triple-quantum filtered NMR imaging of sodium in the human brain
|h [electronic resource]
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| 260 |
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|a Washington, D.C. :
|b United States. Department of Energy. ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
|c 1993.
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| 300 |
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|a 95 p. :
|b digital, PDF file.
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|a text
|b txt
|2 rdacontent.
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|a computer
|b c
|2 rdamedia.
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|a online resource
|b cr
|2 rdacarrier.
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|a Published through SciTech Connect.
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|a 04/01/1993.
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|a "lbl--34375"
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|a "DE93040607"
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|a ": Grant HL 25840"
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|a "Grant HL 07367"
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|a "Grant 89-20133"
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|a John Robinson Keltner.
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|a Thesis (Ph.D.); PBD: Apr 1993.
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|a In the past multiple-quantum filtered imaging of biexponential relaxation sodium-23 nuclei in the human brain has been limited by low signal to noise ratios; this thesis demonstrates that such imaging is feasible when using a modified gradient-selected triple-quantum filter at a repetition time which maximizes the signal to noise ratio. Nuclear magnetic resonance imaging of biexponential relaxation sodium-23 (<sup>23</sup>Na) nuclei in the human brain may be useful for detecting ischemia, cancer, and pathophysiology related to manic-depression. Conventional single-quantum NMR imaging of in vivo biexponential relaxation <sup>23</sup>Na signals is complicated by the presence of single-exponential relaxation <sup>23</sup>Na signals. Multiple-quantum filters may be used to selectively image biexponential relaxation <sup>23</sup>Na signals since these filters suppress single-exponential relaxation <sup>23</sup>Na signals. In this thesis, the typical repetition times (200--300 ms) used for in vivo multiple-quantum filtered <sup>23</sup>Na experiments are shown to be approximately 5 times greater than the optimal repetition time which maximizes multiple-quantum filtered SNR. Calculations and experimental verification show that the gradient-selected triple-quantum (GS3Q) filtered SNR for <sup>23</sup>Na in a 4% agarose gel increases by a factor of two as the repetition time decreases from 300 ms to 55 ms. The measured relaxation times of the <sup>23</sup>Na in the 4% agarose gel were similar to in vivo <sup>23</sup>Na relaxation times.
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|b AC03-76SF00098.
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|a Brain.
|2 local.
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|a Nuclear Magnetic Resonance.
|2 local.
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|a Sodium 23.
|2 local.
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|a Patients.
|2 local.
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|a Hamiltonians.
|2 local.
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|a Radiology And Nuclear Medicine.
|2 edbsc.
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| 650 |
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|a Basic Biological Sciences.
|2 edbsc.
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| 710 |
2 |
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|a Lawrence Berkeley National Laboratory.
|4 res.
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| 710 |
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|a United States.
|b Department of Energy.
|4 spn.
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| 710 |
1 |
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|a United States.
|b Department of Health and Human Services.
|4 spn.
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| 710 |
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|a National Science Foundation (U.S.).
|4 spn.
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| 710 |
1 |
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
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| 856 |
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|u http://www.osti.gov/scitech/biblio/10184286
|z Online Access (via OSTI)
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| 907 |
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|a .b59567004
|b 03-09-23
|c 05-25-10
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| 998 |
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|a web
|b 05-12-17
|c f
|d m
|e p
|f eng
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|h 0
|i 3
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|a Information bridge
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|s dae07fab-0f55-5ed2-b994-b60bbfd78c4d
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| 952 |
f |
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|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:lbl--34375
|h Superintendent of Documents classification
|i web
|n 1
|
