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Nuclear Medicine Program progress report for quarter ending September 30, 1992 [electronic resource]

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Bibliographic Details
Online Access:	Online Access
Corporate Author:	Oak Ridge National Laboratory (Researcher)
Format:	Government Document Electronic eBook
Language:	English
Published:	Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Defense ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 1992.
Subjects:	Beta Decay Radioisotopes. Heavy Nuclei. Nervous System. Document Types. Mammals. Rhenium Isotopes. Drugs. Organs. Autonomic Nervous System Agents. Chemical Preparation. Even-even Nuclei. Labelling. Electron Capture Radioisotopes. Tissue Distribution. Isotopes. Iodine Isotopes. Kidneys. Isomeric Transition Isotopes. Progress Report. Respiratory System. Synthesis. Cardiovascular System. Minutes Living Radioisotopes. Endocrine Glands. Medicine. Glands. Body. Vertebrates. Internal Conversion Radioisotopes. Radioisotopes. Days Living Radioisotopes. Labelled Compounds. Beta-minus Decay Radioisotopes. Tungsten Isotopes. Liver. Lungs. Cerebellum. Central Nervous System. Brain. Animals. Tungsten 188. Rodents. Thyroid. Radiopharmaceuticals. Intermediate Mass Nuclei. Nuclear Medicine. Iodine 125. Odd-even Nuclei. Odd-odd Nuclei. Heart. Rats. Cerebrum. Radioisotope Generators. Digestive System. Rhenium 188. Distribution. Parasympatholytics. Nuclei. Hours Living Radioisotopes. Radiology And Nuclear Medicine.

Description
Abstract:	The radioiodination and in vivo evaluation of p-iodocaramiphen a muscarinic antagonist which binds with high affinity to the M[sub 1] receptor subtype in vitro are described. Biodistribution studies in female Fischer rats demonstrated that [[sup 125]I]-piodocaraminphen had significant cerebral localization, but the uptake did not demonstrate specific uptake in those cerebral regions rich in muscarinic receptors, and radioactivity washed out rapidly from the brain. In addition there was no significant blockage of activity when the rats were preinjected with quinuclidinyl benzilate. These results suggest that p-iodocaramiphen is not a good candidate for the in vivo study of M[sub 1] muscarinic receptor populations by SPECT. Because of the widespread interest and expected importance of the availability of large amounts of tungsten-188 required for the tungsten-188/rhenium-188 generator systems, we have investigated the large-scale production of tungsten-188 in the ORNL HFIR. We have also compared our production data with the theoretical production values and with experimental data available in the literature from other reactors. Tungsten-188 is produced in a fission nuclear reactor by double neutron capture of tungsten-186. The experimental yield of tungsten-188 is approximately 4 mCi/mg of tungsten-186 at the end of bombardment (EOB) in the HFIR operating at 85 MWt power for a one cycle irradiation ([approximately]21 days) at a thermal neutron flux of 2 [times] 10[sup 15] n.s[sup [minus]1]cm[sup [minus]2]
Item Description:	Published through the Information Bridge: DOE Scientific and Technical Information. 12/01/1992. "ornl/tm-1222" "DE93003548" Lambert, C.R.; Knapp, F.F. Jr.; Hasan, A.; Ambrose, K.R.; Mirzadeh, S.; Callahan, A.P.; Beets, A.L.; McPherson, D.W.
Physical Description:	Pages: (20 p) : digital, PDF file.