Increased IMP dehydrogenase gene expression in solid tumor tissues and tumor cell lines [electronic resource]
Saved in:
| Online Access: |
Online Access |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Dept. of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
1992.
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| Subjects: |
| Abstract: | IMP dehydrogenase, a regulatory enzyme of guanine nucleotide biosynthesis, may play a role in cell proliferation and malignancy. To assess this possibility, we examined IMP dehydrogenase expression in a series of human solid tumor tissues and tumor cell lines in comparison with their normal counterparts. Increased IMP dehydrogenase gene expression was observed in brain tumors relative to normal brain tissue and in sarcoma cells relative to normal fibroblasts. Similarly, in several B- and T-lymphoid leukemia cell lines, elevated levels of IMP dehydrogenase mRNA and cellular enzyme were observed in comparison with the levels in peripheral blood lymphocytes. These results are consistent with an association between increased IMP dehydrogenase expression and either enhanced cell proliferation or malignant transformation. |
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| Item Description: | Published through the Information Bridge: DOE Scientific and Technical Information. 07/10/1992. "anl/bim/pp--74812" "DE94011495" Huberman, E.; Collart, F.R.; Chubb, C.B.; Mirkin, B.L. |
| Physical Description: | 11 p. : digital, PDF file. |
| Type of Report and Period Covered Note: | Topical; |