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|a (TOE)ost6482460
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|a (TOE)6482460
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|a TOE
|c TOE
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|a GDWR
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|a 63
|2 edbsc
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| 086 |
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|a E 1.99: conf-9008142--2
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| 086 |
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|a E 1.99:ucrl-jc-104817
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| 086 |
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|a E 1.99: conf-9008142--2
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| 245 |
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|a Laser-based flow cytometric analysis of genotoxicity of humans exposed to ionizing radiation during the Chernobyl accident
|h [electronic resource]
|
| 260 |
|
|
|a Washington, D.C :
|b United States. Dept. of Energy. Office of Energy Research ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 1990.
|
| 300 |
|
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|a Pages: (9 p) :
|b digital, PDF file.
|
| 336 |
|
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|a text
|b txt
|2 rdacontent.
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| 337 |
|
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 500 |
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|a Published through the Information Bridge: DOE Scientific and Technical Information.
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| 500 |
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|a 09/12/1990.
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| 500 |
|
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|a "ucrl-jc-104817"
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| 500 |
|
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|a " conf-9008142--2"
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| 500 |
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|a "DE91000809"
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| 500 |
|
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|a Laser applications in life science, Moscow (USSR), 17-31 Aug 1990.
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| 500 |
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|a Jensen, R.H.; Bigbee, W.L.; Langlois, R.G.; Chirkov, A.A.; Grant, S.G.; Pilinskaya, M.A.; Pleshanov, P.G.
|
| 520 |
3 |
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|a An analytical technique has been developed that allows laser-based flow cytometric measurement of the frequency of red blood cells that have lost allele-specific expression of a cell surface antigen due to genetic toxicity in bone marrow precursor cells. Previous studies demonstrated a correlation of such effects with the exposure of each individual to mutagenic phenomena, such as ionizing radiation, and the effects can persist for the lifetime of each individual. During the emergency response to the nuclear power plant accident at Chernobyl, Ukraine, USSR, a number of people were exposed to whole body doses of ionizing radiation. Some of these individuals were tested with this laser-based assay and found to express a dose-dependent increase in the frequency of variant red blood cells that appears to be a persistent biological effect. All data indicate that this assay might well be used as a biodosimeter to estimate radiation dose and also as an element to be used for estimating the risk of each individual to develop cancer due to radiation exposure. 17 refs., 5 figs.
|
| 536 |
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|b W-7405-ENG-48.
|
| 650 |
|
7 |
|a Dosimetry.
|2 local.
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| 650 |
|
7 |
|a Genetic Effects.
|2 local.
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| 650 |
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7 |
|a Blood.
|2 local.
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| 650 |
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7 |
|a Whole-body Counting.
|2 local.
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| 650 |
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7 |
|a Chernobylsk-4 Reactor.
|2 local.
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| 650 |
|
7 |
|a Radiation Doses.
|2 local.
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| 650 |
|
7 |
|a Blood Chemistry.
|2 local.
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| 650 |
|
7 |
|a Blood Cells.
|2 local.
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| 650 |
|
7 |
|a Somatic Cells.
|2 local.
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| 650 |
|
7 |
|a Graphite Moderated Reactors.
|2 local.
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| 650 |
|
7 |
|a Biological Radiation Effects.
|2 local.
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| 650 |
|
7 |
|a Radiation Effects.
|2 local.
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| 650 |
|
7 |
|a Power Reactors.
|2 local.
|
| 650 |
|
7 |
|a Human Populations.
|2 local.
|
| 650 |
|
7 |
|a Counting Techniques.
|2 local.
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| 650 |
|
7 |
|a Mutations.
|2 local.
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| 650 |
|
7 |
|a Thermal Reactors.
|2 local.
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| 650 |
|
7 |
|a Bone Marrow Cells.
|2 local.
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| 650 |
|
7 |
|a Biological Effects.
|2 local.
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| 650 |
|
7 |
|a Populations.
|2 local.
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| 650 |
|
7 |
|a Materials.
|2 local.
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| 650 |
|
7 |
|a Ionizing Radiations.
|2 local.
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| 650 |
|
7 |
|a Erythrocytes.
|2 local.
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| 650 |
|
7 |
|a Water Cooled Reactors.
|2 local.
|
| 650 |
|
7 |
|a Biological Materials.
|2 local.
|
| 650 |
|
7 |
|a Reactors.
|2 local.
|
| 650 |
|
7 |
|a Irradiation.
|2 local.
|
| 650 |
|
7 |
|a Enriched Uranium Reactors.
|2 local.
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| 650 |
|
7 |
|a Bioassay.
|2 local.
|
| 650 |
|
7 |
|a Chromosomal Aberrations.
|2 local.
|
| 650 |
|
7 |
|a Animal Cells.
|2 local.
|
| 650 |
|
7 |
|a Body Fluids.
|2 local.
|
| 650 |
|
7 |
|a Pathogenesis.
|2 local.
|
| 650 |
|
7 |
|a Carcinogenesis.
|2 local.
|
| 650 |
|
7 |
|a External Irradiation.
|2 local.
|
| 650 |
|
7 |
|a Doses.
|2 local.
|
| 650 |
|
7 |
|a Connective Tissue Cells.
|2 local.
|
| 650 |
|
7 |
|a Radiations.
|2 local.
|
| 650 |
|
7 |
|a Environmental Exposure.
|2 local.
|
| 650 |
|
7 |
|a Genetic Radiation Effects.
|2 local.
|
| 650 |
|
7 |
|a Toxicity.
|2 local.
|
| 650 |
|
7 |
|a Lwgr Type Reactors.
|2 local.
|
| 650 |
|
7 |
|a Accidents.
|2 local.
|
| 650 |
|
7 |
|a Cell Flow Systems.
|2 local.
|
| 650 |
|
7 |
|a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..
|2 edbsc.
|
| 710 |
2 |
|
|a Lawrence Livermore National Laboratory.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Energy Research.
|4 spn.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
0 |
|u http://www.osti.gov/servlets/purl/6482460-GW9ku9/
|z Online Access
|
| 907 |
|
|
|a .b5979110x
|b 03-06-23
|c 05-26-10
|
| 998 |
|
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|a web
|b 05-26-10
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|f eng
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|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99: conf-9008142--2
|h Superintendent of Documents classification
|i web
|n 1
|
