Method for distinguishing normal and transformed cells using G1 kinase inhibitors [electronic resource]
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| Online Access: |
Online Access |
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| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Dept. of Energy ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
1991.
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| Subjects: |
| Abstract: | A G₁ phase kinase inhibitor is applied in a low concentration to a population of normal and transformed mammalian cells. The concentration of G₁ phase kinase inhibitor is selected to reversibly arrest normal mammalian cells in the G₁ cell cycle without arresting growth of transformed cells. The transformed cells may then be selectively identified and/or cloned for research or diagnostic purposes. The transformed cells may also be selectively killed by therapeutic agents that do not affect normal cells in the G₁ phase, suggesting that such G₁ phase kinase inhibitors may form an effective adjuvant for use with chemotherapeutic agents in cancer therapy for optimizing the killing dose of chemotherapeutic agents while minimizing undesirable side effects on normal cells. |
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| Item Description: | Published through the Information Bridge: DOE Scientific and Technical Information. 12/31/1991. "patents-us--a7751855" "DE93019324" ": US patent application 7-751,855" Crissman, H.A.; Tobey, R.A.; Gadbois, D.M.; Bradbury, E.M. |
| Physical Description: | 20 p. : digital, PDF file. |
| Terms Governing Use and Reproduction Note: | Dept. of Energy. |