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Analyses of critical target cell responses during preclinical phases of evolving chronic radiation-induced myeloproliferative disease-exploitation of a unique canine model [electronic resource]

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Bibliographic Details
Online Access: Online Access
Corporate Authors: Argonne National Laboratory (Researcher), Pacific Northwest Laboratory (Researcher)
Format: Government Document Electronic eBook
Language:English
Published: Argonne, Ill. : Oak Ridge, Tenn. : Argonne National Lab ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 1988.
Subjects:
Transformations.
Ionizing Radiations.
Diseases.
Mammals.
Irradiation.
Bioassay.
Animal Cells.
Pathogenesis.
Dogs.
Low Dose Irradiation.
Carcinogenesis.
Electromagnetic Radiation.
Radiations.
Leukemogenesis.
Vertebrates.
Animals.
Radioinduction.
Gamma Radiation.
Neoplasms.
Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..
Description
Abstract:This document briefly summarizes and highlights ongoing studies on the cellular and molecular processes involved in the induction and progression of myeloid leukemia in dogs chronically exposed to low daily doses of wholebody gamma irradiation. Under such conditions, select groups of dogs exhibit extremely high frequencies of myeloproliferative disease (MPD) (i.e., ≅50%) of which myeloid leukemia is most prominent. 2 figs.
Item Description:Published through the Information Bridge: DOE Scientific and Technical Information.
01/01/1988.
"conf-881070-3"
"DE89007503"
Symposium on multi-level health effects research: molecules to man, Richland, WA, USA, 17 Oct 1988.
Fritz, T.E.; Tolle, D.V.; Kaspar, L.V.; Seed, T.M.; Frazier, M.E.
Physical Description:Pages: 17 : digital, PDF file.

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