Enzyme- and transporter-based drug-drug Interactions [electronic resource] : progress and future challenges / K. Sandy Pang, A. David Rodrigues, Raimund M. Peter, editors.
This volume is authored by esteemed experts in the field, and provides state-of-the art knowledge related to enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs. It examines the types of DDIs, methodological approaches to evaluate and view DDIs mechanistically, bio...
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| Format: | Electronic eBook |
| Language: | English |
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New York :
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©2010.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Enzyme- and transporter-based drug-drug Interactions |h [electronic resource] : |b progress and future challenges / |c K. Sandy Pang, A. David Rodrigues, Raimund M. Peter, editors. |
| 260 | |a New York : |b Springer, |c ©2010. | ||
| 300 | |a 1 online resource (xviii, 746 pages) : |b illustrations. | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Preface; Contents; Contributors; About the Editors; Part I Determinants of Drug ADME; 1 Enzymatic Basis of Phase I and Phase II Drug Metabolism; References; 2 Transporters: Importance in Drug Absorption, Distribution, and Removal; References; 3 ADME Pharmacogenetics and Its Impact on DrugDrug Interactions; References; 4 Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters; References; 5 Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and TotalBody Clearances; References. | |
| 520 | |a This volume is authored by esteemed experts in the field, and provides state-of-the art knowledge related to enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs. It examines the types of DDIs, methodological approaches to evaluate and view DDIs mechanistically, bioinformatics, clinical and toxicological outcomes, and regulatory recommendations. As much as possible, the future challenges and opportunities that lie ahead are presented and discussed. Special emphases are placed on the quantitative assessment of the roles of different transporters, need for more specific probes and inhibitors, and recognition of extrahepatic eliminating organs. Future approaches should integrate transporters and enzymes to accelerate the development of physiological based-pharmacokinetic models (PBPK-DDI) and information related to inter-subject variability. In addition, the authors look beyond small molecules and consider DDIs involving biologic agents, such as therapeutic antibodies, that can bring about pharmacologically significant drug-cytokine or drug-endocrine interactions. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Drug interactions. |0 http://id.loc.gov/authorities/subjects/sh85039701. | |
| 650 | 0 | |a Biological transport. |0 http://id.loc.gov/authorities/subjects/sh85014197. | |
| 650 | 7 | |a Biological transport. |2 fast |0 (OCoLC)fst00832345. | |
| 650 | 7 | |a Drug interactions. |2 fast |0 (OCoLC)fst00898681. | |
| 700 | 1 | |a Pang, K. Sandy. |0 http://id.loc.gov/authorities/names/n2010181792. | |
| 700 | 1 | |a Rodrigues, A. David. |0 http://id.loc.gov/authorities/names/n2002132865 |1 http://isni.org/isni/0000000045223516. | |
| 700 | 1 | |a Peter, Raimund M. |0 http://id.loc.gov/authorities/names/n2010181794. | |
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