Enzyme- and transporter-based drug-drug Interactions [electronic resource] : progress and future challenges / K. Sandy Pang, A. David Rodrigues, Raimund M. Peter, editors.
This volume is authored by esteemed experts in the field, and provides state-of-the art knowledge related to enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs. It examines the types of DDIs, methodological approaches to evaluate and view DDIs mechanistically, bio...
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| Format: | Electronic eBook |
| Language: | English |
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New York :
Springer,
©2010.
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Table of Contents:
- Preface; Contents; Contributors; About the Editors; Part I Determinants of Drug ADME; 1 Enzymatic Basis of Phase I and Phase II Drug Metabolism; References; 2 Transporters: Importance in Drug Absorption, Distribution, and Removal; References; 3 ADME Pharmacogenetics and Its Impact on DrugDrug Interactions; References; 4 Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters; References; 5 Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and TotalBody Clearances; References.