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|a (TOE)ost834631
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|a lbnl--53764
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|a Independent effects of apolipoprotein AV and apolipoprotein CIII on plasma triglyceride concentrations
|h [electronic resource]
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| 260 |
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|a Berkeley, Calif. :
|b Lawrence Berkeley National Laboratory ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 2003.
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| 300 |
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|a vp. :
|b digital, PDF file.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 500 |
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|a Published through the Information Bridge: DOE Scientific and Technical Information.
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| 500 |
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|a 08/15/2003.
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| 500 |
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|a "lbnl--53764"
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|a Arteriosclerosis, Thrombosis & Vascular Biology 24 7 FT.
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| 500 |
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|a Rubin, Edward M.; Pennacchio, Len A.; Akiyama, Jennifer; Fruchart, Jean-Charles; Baroukh, Nadine N.; Bauge, Eric; Chang, Jessie; Fruchart, Jamila.
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| 500 |
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|a USDOE Director. Office of Science. Office of Biological and Environmental Research. Life Science Division.
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| 500 |
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|a National Institutes of Health. National Heart, Lung, and Blood Institute. Programs for Genomic Application Grants HL66681 and HL071954A (US)
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| 520 |
3 |
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|a Both the apolipoprotein A5 and C3 genes have repeatedly been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. In mice, transgenic and knockout experiments indicate that plasma triglyceride levels are negatively and positively correlated with APOA5 and APOC3 expression, respectively. In humans, common polymorphisms in both genes have also been associated with plasma triglyceride concentrations. The evolutionary relationship among these two apolipoprotein genes and their close proximity on human chromosome 11q23 have largely precluded the determination of their relative contribution to altered Both the apolipoprotein A5 and C3 genes have repeatedly been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. In mice, transgenic and knockout experiments indicate that plasma triglyceride levels are negatively and positively correlated with APOA5 and APOC3 expression, respectively. In humans, common polymorphisms in both genes have also been associated with plasma triglyceride concentrations. The evolutionary relationship among these two apolipoprotein genes and their close proximity on human chromosome 11q23 have largely precluded the determination of their relative contribution to altered triglycerides. To overcome these confounding factors and address their relationship, we generated independent lines of mice that either over-expressed (''double transgenic'') or completely lacked (''double knockout'') both apolipoprotein genes. We report that both ''double transgenic'' and ''double knockout'' mice display intermedia tetriglyceride concentrations compared to over-expression or deletion of either gene alone. Furthermore, we find that human ApoAV plasma protein levels in the ''double transgenic'' mice are approximately 500-fold lower than human ApoCIII levels, supporting ApoAV is a potent triglyceride modulator despite its low concentration. Together, these data indicate that APOA5 and APOC3 independently influence plasma triglyceride concentrations but in an opposing manner.
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|b AC03-76SF00098.
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|b 863V3A.
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|a Genes.
|2 local.
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|a Human Chromosomes.
|2 local.
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|a Mice.
|2 local.
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|a Plasma.
|2 local.
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|a Apolipoproteins.
|2 local.
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|a Proteins.
|2 local.
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|a Triglycerides.
|2 local.
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| 650 |
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|a Applied Life Sciences.
|2 edbsc.
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| 650 |
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|a Basic Biological Sciences.
|2 edbsc.
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| 710 |
2 |
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|a Lawrence Berkeley National Laboratory.
|4 res.
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| 710 |
1 |
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
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| 856 |
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|u http://www.osti.gov/servlets/purl/834631-bjsr5r/native/
|z Online Access
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| 907 |
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|a .b69980974
|b 03-06-23
|c 03-31-12
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| 998 |
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|a web
|b 03-31-12
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|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:lbnl--53764
|h Superintendent of Documents classification
|i web
|n 1
|
