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|a (TOE)ost893777
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|a E 1.99:nabir-1011983-2003
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|a E 1.99:nabir-1011983-2003
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| 088 |
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|a nabir-1011983-2003
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| 245 |
0 |
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|a Field-Portable Immunoassay Instruments and Reagents to Measure Chelators and Mobile Forms of Uranium
|h [electronic resource]
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| 260 |
|
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|a Washington, D.C. :
|b United States. Dept. of Energy. Office of Science ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 2003.
|
| 336 |
|
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|a text
|b txt
|2 rdacontent.
|
| 337 |
|
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|a computer
|b c
|2 rdamedia.
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier.
|
| 500 |
|
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|a Published through the Information Bridge: DOE Scientific and Technical Information.
|
| 500 |
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|a 06/01/2003.
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| 500 |
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|a "nabir-1011983-2003"
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| 500 |
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|a Blake, Diane A.
|
| 520 |
3 |
|
|a The goals for the 3-year project period are (1) to test and validate the present uranium sensor and develop protocols for its use at the NABIR Field Research Center; (2) to develop new reagents that will provide superior performance for the present hand-held immunosensor; and (3) to develop new antibodies that will permit this sensor to also measure other environmental contaminants (chromium, mercury, and/or DTPA). Sensor design modifications are underway via international collaborations. New reagents that will provide superior performance for the present hand-held immunosensor are being prepared and tested. New methods have been developed, to produce recombinant forms of metal-specific monoclonal antibodies for use with the sensor. Site-directed mutagenesis experiments are underway to determine the mechanisms of binding. Immunization experiments with sheep and rabbits to develop new recombinant forms of antibodies to metal-chelate complexes (chromium, mercury, and/or DTPA) have been initiated.
|
| 536 |
|
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|b NABIR 1011983.
|
| 650 |
|
7 |
|a Immunoassay.
|2 local.
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| 650 |
|
7 |
|a Design.
|2 local.
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| 650 |
|
7 |
|a Uranium.
|2 local.
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| 650 |
|
7 |
|a Chromium.
|2 local.
|
| 650 |
|
7 |
|a Modifications.
|2 local.
|
| 650 |
|
7 |
|a Monoclonal Antibodies.
|2 local.
|
| 650 |
|
7 |
|a Antibodies.
|2 local.
|
| 650 |
|
7 |
|a Rabbits.
|2 local.
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| 650 |
|
7 |
|a Performance.
|2 local.
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| 650 |
|
7 |
|a Mutagenesis.
|2 local.
|
| 650 |
|
7 |
|a Sheep.
|2 local.
|
| 650 |
|
7 |
|a Mercury.
|2 local.
|
| 650 |
|
7 |
|a Radiation Chemistry, Radiochemistry, And Nuclear Chemistry.
|2 edbsc.
|
| 650 |
|
7 |
|a Applied Life Sciences.
|2 edbsc.
|
| 650 |
|
7 |
|a Environmental Sciences.
|2 edbsc.
|
| 710 |
2 |
|
|a Tulane University.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Science.
|4 spn.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Environmental Management Science Program.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
0 |
|u http://www.osti.gov/servlets/purl/893777-hIm2ho/
|z Online Access
|
| 907 |
|
|
|a .b69995242
|b 03-06-23
|c 03-31-12
|
| 998 |
|
|
|a web
|b 03-31-12
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|h 0
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| 952 |
f |
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|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:nabir-1011983-2003
|h Superintendent of Documents classification
|i web
|n 1
|
