In situ quantification of genomic instability in breast cancer progression [electronic resource]
Image Segmentation Genomic Instability Telomere Crisis Fish.
Saved in:
| Online Access: |
Online Access |
|---|---|
| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Dept. of Energy. Office of Health and Environmental Research ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
2003.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a In situ quantification of genomic instability in breast cancer progression |h [electronic resource] |
| 260 | |a Washington, D.C. : |b United States. Dept. of Energy. Office of Health and Environmental Research ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, |c 2003. | ||
| 300 | |a vp. : |b digital, PDF file. | ||
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| 500 | |a Published through the Information Bridge: DOE Scientific and Technical Information. | ||
| 500 | |a 05/15/2003. | ||
| 500 | |a "lbnl--52688" | ||
| 500 | |a 25th annual international conference of the IEEE engineering in medicine and biology society, Cancun (MX), 09/17/2003--09/21/2003. | ||
| 500 | |a Gray, Joe W.; Ortiz de Solorzano, Carlos; Lockett, Stephen J.; Chin, Koei. | ||
| 500 | |a NIH contract N01-CO-56000. NIH grants CA67412 and CA58207, DOD grants DAM D17-00-1-0227 and DAMD17-00-1-0306. | ||
| 500 | |a Carl Zeiss, Inc. (US) | ||
| 520 | 3 | |a Genomic instability is a hallmark of breast and other solid cancers. Presumably caused by critical telomere reduction, GI is responsible for providing the genetic diversity required in the multi-step progression of the disease. We have used multicolor fluorescence in situ hybridization and 3D image analysis to quantify genomic instability cell-by-cell in thick, intact tissue sections of normal breast epithelium, preneoplastic lesions (usual ductal hyperplasia), ductal carcinona is situ or invasive carcinoma of the breast. Our in situ-cell by cell-analysis of genomic instability shows an important increase of genomic instability in the transition from hyperplasia to in situ carcinoma, followed by a reduction of instability in invasive carcinoma. This pattern suggests that the transition from hyperplasia to in situ carcinoma corresponds to telomere crisis and invasive carcinoma is a consequence of telomerase reactivation afertelomere crisis. | |
| 520 | 0 | |a Image Segmentation Genomic Instability Telomere Crisis Fish. | |
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| 650 | 7 | |a Biology. |2 local. | |
| 650 | 7 | |a Medicine. |2 local. | |
| 650 | 7 | |a Genetics. |2 local. | |
| 650 | 7 | |a Instability. |2 local. | |
| 650 | 7 | |a Fluorescence. |2 local. | |
| 650 | 7 | |a Telomeres. |2 local. | |
| 650 | 7 | |a Epithelium. |2 local. | |
| 650 | 7 | |a Neoplasms. |2 local. | |
| 650 | 7 | |a Carcinomas. |2 local. | |
| 650 | 7 | |a Mammary Glands. |2 local. | |
| 650 | 7 | |a In-situ Hybridization. |2 local. | |
| 650 | 7 | |a Applied Life Sciences. |2 edbsc. | |
| 650 | 7 | |a Basic Biological Sciences. |2 edbsc. | |
| 710 | 2 | |a Lawrence Berkeley National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Health and Environmental Research. |4 spn. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
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