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|a (TOE)ost15013638
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|a (TOE)15013638
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|a E 1.99:ucrl-jrnl-200184
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|a E 1.99:ucrl-jrnl-200184
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|a ucrl-jrnl-200184
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|a Taking X-ray Diffraction to the Limit
|h [electronic resource] :
|b Macromolecular Structures from Femtosecond X-ray Pulses and Diffraction Microscopy of Cells with Synchrotron Radiation.
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|a Washington, D.C. :
|b United States. Department of Energy. ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
|c 2003.
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|a PDF-file: 23 pages; size: 0.8 Mbytes.
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|a text
|b txt
|2 rdacontent.
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|a computer
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|a online resource
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|a Published through SciTech Connect.
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|a 10/01/2003.
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|a "ucrl-jrnl-200184"
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|a Annual Review of Biophysics and Biomolecular Structure 33 FT.
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|a Chapman, H N; Miao, J; Kirz, J; Sayre, D; Hodgson, K O.
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|a The methodology of X-ray crystallography has recently been successfully extended to the structure determination of non-crystalline specimens. The phase problem was solved by using the oversampling method, which takes advantage of ''continuous'' diffraction pattern from non-crystalline specimens. Here we review the principle of this newly developed technique and discuss the ongoing experiments of imaging non-periodic objects, like cells and cellular structures using coherent and bright X-rays from the 3rd generation synchrotron radiation. In the longer run, the technique may be applied to image single biomolecules by using the anticipated X-ray free electron lasers. Computer simulations have so far demonstrated two important steps: (1) by using an extremely intense femtosecond X-ray pulse, a diffraction pattern can be recorded from a macromolecule before radiation damage manifests itself, and (2) the phase information can be ab initio retrieved from a set of calculated noisy diffraction patterns of single protein molecules.
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|b W-7405-ENG-48.
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|a Computerized Simulation.
|2 local.
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|a Crystallography.
|2 local.
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| 650 |
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|a Free Electron Lasers.
|2 local.
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|a Microscopy.
|2 local.
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|a Proteins.
|2 local.
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|a Synchrotron Radiation.
|2 local.
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|a X-Ray Diffraction.
|2 local.
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|a Cell Constituents.
|2 local.
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| 650 |
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|a Basic Biological Sciences.
|2 edbsc.
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| 710 |
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|a Lawrence Berkeley National Laboratory.
|4 res.
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| 710 |
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|a United States.
|b Department of Energy.
|4 spn.
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| 710 |
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
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| 856 |
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|u http://www.osti.gov/scitech/biblio/15013638
|z Online Access (via OSTI)
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|a .b70127633
|b 03-09-23
|c 03-31-12
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|a web
|b 05-20-19
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|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:ucrl-jrnl-200184
|h Superintendent of Documents classification
|i web
|n 1
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