The BDGP gene disruption project [electronic resource] : Single transposon insertions associated with 40 percent of Drosophila genes.
Drosophila Transposon P-element Piggybac Mutagenesis.
Saved in:
| Online Access: |
Online Access |
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| Corporate Author: | |
| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Berkeley, Calif. : Oak Ridge, Tenn. :
Lawrence Berkeley National Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
2004.
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| Subjects: |
MARC
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| 245 | 0 | 4 | |a The BDGP gene disruption project |h [electronic resource] : |b Single transposon insertions associated with 40 percent of Drosophila genes. |
| 260 | |a Berkeley, Calif. : |b Lawrence Berkeley National Laboratory ; |a Oak Ridge, Tenn. : |b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, |c 2004. | ||
| 300 | |a vp. : |b digital, PDF file. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
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| 500 | |a Published through the Information Bridge: DOE Scientific and Technical Information. | ||
| 500 | |a 01/13/2004. | ||
| 500 | |a "lbnl--55213" | ||
| 500 | |a Genetics 167 2 ISSN 0016-6731; GENTAE FT. | ||
| 500 | |a Hoskins, Roger A.; Rubin, Gerald M.; Evans-Holm, Martha; Liao, Guochun; Carlson, Joseph W.; Bellen, Hugo J.; Levis, Robert W.; He, Yuchun; Hiesinger, P. Robin; Schulze, Karen L.; Spradling, Allan C.; Tsang, Garson. | ||
| 500 | |a National Institutes of Health Drosophila Genome Center Grant GMR PI. Special supplement ACS PI. National Institute of General Medical Sciences. | ||
| 500 | |a Howard Hughes Medical Institute. Spradling Bellen and Rubin Labs, Baylor College of Medicine LB04-BG0227200 (US) | ||
| 520 | 3 | |a The Berkeley Drosophila Genome Project (BDGP) strives to disrupt each Drosophila gene by the insertion of a single transposable element. As part of this effort, transposons in more than 30,000 fly strains were localized and analyzed relative to predicted Drosophila gene structures. Approximately 6,300 lines that maximize genomic coverage were selected to be sent to the Bloomington Stock Center for public distribution, bringing the size of the BDGP gene disruption collection to 7,140 lines. It now includes individual lines predicted to disrupt 5,362 of the 13,666 currently annotated Drosophila genes (39 percent). Other lines contain an insertion at least 2 kb from others in the collection and likely mutate additional incompletely annotated or uncharacterized genes and chromosomal regulatory elements. The remaining strains contain insertions likely to disrupt alternative gene promoters or to allow gene mis-expression. The expanded BDGP gene disruption collection provides a public resource that will facilitate the application of Drosophila genetics to diverse biological problems. Finally, the project reveals new insight into how transposons interact with a eukaryotic genome and helps define optimal strategies for using insertional mutagenesis as a genomic tool. | |
| 520 | 0 | |a Drosophila Transposon P-element Piggybac Mutagenesis. | |
| 536 | |b AC03-76SF00098. | ||
| 536 | |b L0111. | ||
| 650 | 7 | |a Genes. |2 local. | |
| 650 | 7 | |a Drosophila. |2 local. | |
| 650 | 7 | |a Genetics. |2 local. | |
| 650 | 7 | |a Strains. |2 local. | |
| 650 | 7 | |a Transposons. |2 local. | |
| 650 | 7 | |a Distribution. |2 local. | |
| 650 | 7 | |a Mutagenesis. |2 local. | |
| 650 | 7 | |a Promoters. |2 local. | |
| 650 | 7 | |a Basic Biological Sciences. |2 edbsc. | |
| 710 | 2 | |a Lawrence Berkeley National Laboratory. |4 res. | |
| 710 | 1 | |a United States. |b Department of Energy. |b Office of Scientific and Technical Information. |4 dst. | |
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