Drug resistance in leishmania parasites [electronic resource] : consequences, molecular mechanisms and possible treatments / Alicia Ponte-Sucre, Emilia Díaz, Maritza Padrón-Nieves, editors.
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These...
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Springer,
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Table of Contents:
- Part 1. DETERMINANT FEATURES IN LEISHMANIASIS
- Molecular Evolution and Phylogeny of Leishmania / Gabriele Schönian, Elisa Cupolillo and Isabel Mauricio
- The Role of Reservoirs: Canine Leishmaniasis / Lenea Campino and Carla Maia
- Epidemiology of Leishmaniasis in the Time of Drug Resistance / Jean-Claude Dujardin and Saskia Decuypere
- Introduction: Leishmaniasis
- The Biology of a Parasite / A. Ponte-Sucre.
- Part 2. Leishmania and the Immune System
- The Role of the Immune System in Resistance to Infection / Lukasz Kedzierski and Krystal J. Evans
- Vaccination as a Control Measure / Katrin Färber and Heidrun Moll
- Leishmania Vaccines: Past, Present, and Future / Bhavana Sethu Lakshmi and Rentala Madhubala.
- Part 3. CHALLENGES IN THE DIAGNOSIS, TREATMENT AND CONTROL OF LEISHMANIASIS IN TIMES OF DRUG RESISTANCE
- Co-infection with HIV / Margriet den Boer, Luis Rivas and Jorge Alvar
- Visceral Leishmaniasis / Shyam Sundar and Jaya Chakravarty
- American Tegumentary Leishmaniasis / Olga Zerpa and Alicia Ponte-Sucre.
- Part 4. MOLECULAR FEATURES OF DRUG-RESISTANT LEISHMANIA
- Genetic Expression and Drug Resistance, the Role of Proteomics / Patricia Cuervo and Jose Batista de Jesus
- The Role of ABC Transporters in Drug-Resistant Leishmania / Adriano C. Coelho and Paulo C. Cotrim
- Functional Analysis of Leishmania Membrane (Non-ABC) Transporters Involved in Drug Resistance / Scott M. Landfear
- Intracellular Mechanisms of Resistance / Mitali Chatterjee.
- Part 5. PHARMACOLOGY AND CHEMOTHERAPY OF LEISHMANIASIS
- Classical Versus Novel Treatment Regimens / Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos and Vanessa Yardley
- Drug Targets, Drug Effectors, and Drug Targeting and Delivery / Philippe M. Loiseau and Gillian Barratt
- Mechanisms of Miltefosine Resistance in Leishmania / Francisco Gamarro, María P. Sánchez-Cañete and Santiago Castanys
- P-glycoprotein-like Transporters in Leishmania: A Search for Reversal Agents / Bruno Pradines.
- Part 6. STRATEGIES TO CIRCUMVENT DRUG RESISTANCE IN LEISHMANIA
- The Relevance of Susceptibility Tests, Breakpoints, and Markers / Louis Maes, Paul Cos and Simon L. Croft
- The Concept of Fitness and Drug Resistance in Leishmania / Alicia Ponte-Sucre, Emilia Diaz and Maritza Padrón-Nieves.