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140422e19780313alu o| f1|||||eng|d |
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|a (TOE)ost6933831
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|a (TOE)6933831
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|a TOE
|c TOE
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|a GDWR
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|a 63
|2 edbsc
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| 086 |
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|a E 1.99:conf-780306-8
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| 086 |
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|a E 1.99:conf-780306-8
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| 088 |
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|a conf-780306-8
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| 245 |
0 |
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|a Analytical approaches to and interpretations of data on time, rate, and cause of death of mice exposed to external gamma irradiation
|h [electronic resource]
|
| 260 |
|
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|a Normal, Ala. :
|b Alabama A & M University ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
|c 1978.
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| 300 |
|
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|a Pages: 17 :
|b digital, PDF file.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 500 |
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|a Published through SciTech Connect.
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| 500 |
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|a 03/13/1978.
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| 500 |
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|a "conf-780306-8"
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| 500 |
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|a Symposium on late biological effects of ionizing radiation, Vienna, Austria, 13 Mar 1978.
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| 500 |
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|a Grahn, D; Sacher, G A; Lea, R A; Fry, R J.M.; Rust, J H.
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| 520 |
3 |
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|a Young adult male and female mice of inbred strains, A, BALB/c, C57BL/6, and C57L, and B6CF₁ and F₂ hybrids were exposed to daily duration-of-life external ⁶°Co ..gamma.. irradiation. Age at death was recorded, and most decedents were necropsied to ascertain occurrence of major types of tumors. Age- and cause-specific mortality or incidence rates were derived, and their regressions on age were fitted with polynomial equations by least-squares procedures. Age-specific and age-adjusted integrated lifetime risk in excess of the control population was expressed as the mortality ratio (irradiated/control). Linear and nonlinear functions and widely different life expectancies can be accommodated by this technique. These basic actuarial statistics provide a means for comparative analysis of dose-response functions, sex and genetic variables, relative vs. absolute risk, protraction or dose-rate factors, and major contributing causes of excess risk. They also provide a basis for extrapolation to man. As examples, life shortening in days per rad (4 days/100 rads accumulated) is generally independent of sex, genotype, and daily dose rate. The integrated average lifetime risk of death related to all tumors (0.025%/rad) is largely independent of sex, genotype and dose-rates <12 rads/day, despite the fact that tumor incidence varies by a factor of 2 to 3 among genotypes. At low exposure rates, tumor-related mortality accounts for 80% of the excess risk, and life shortening is a function only of accumulated dose, independent of dose rate below 12 rads/day. The radiobiological effectiveness for low daily exposure levels is less than that for single exposures by a factor of 5 to 10. Life shortening following low daily exposure rates is induced at the rate of .03 to .06 days/R for the mouse, which extrapolates to about 1 to 2 days/R for man.
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| 536 |
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|b W-31-109-ENG-38.
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| 650 |
|
7 |
|a Beta Decay Radioisotopes.
|2 local.
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| 650 |
|
7 |
|a Genetic Variability.
|2 local.
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| 650 |
|
7 |
|a Mice.
|2 local.
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| 650 |
|
7 |
|a Mammals.
|2 local.
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| 650 |
|
7 |
|a Biological Radiation Effects.
|2 local.
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| 650 |
|
7 |
|a Electromagnetic Radiation.
|2 local.
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| 650 |
|
7 |
|a Isotopes.
|2 local.
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| 650 |
|
7 |
|a Primates.
|2 local.
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| 650 |
|
7 |
|a Dose-response Relationships.
|2 local.
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| 650 |
|
7 |
|a Whole-body Irradiation.
|2 local.
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| 650 |
|
7 |
|a Biological Variability.
|2 local.
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| 650 |
|
7 |
|a Diseases.
|2 local.
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| 650 |
|
7 |
|a Ionizing Radiations.
|2 local.
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| 650 |
|
7 |
|a Isomeric Transition Isotopes.
|2 local.
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| 650 |
|
7 |
|a Mathematics.
|2 local.
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| 650 |
|
7 |
|a Irradiation.
|2 local.
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| 650 |
|
7 |
|a Minutes Living Radioisotopes.
|2 local.
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| 650 |
|
7 |
|a Life Span.
|2 local.
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| 650 |
|
7 |
|a Chronic Exposure.
|2 local.
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| 650 |
|
7 |
|a External Irradiation.
|2 local.
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| 650 |
|
7 |
|a Low Dose Irradiation.
|2 local.
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| 650 |
|
7 |
|a Vertebrates.
|2 local.
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| 650 |
|
7 |
|a Mortality.
|2 local.
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| 650 |
|
7 |
|a Internal Conversion Radioisotopes.
|2 local.
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| 650 |
|
7 |
|a Rbe.
|2 local.
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| 650 |
|
7 |
|a Radioisotopes.
|2 local.
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| 650 |
|
7 |
|a Beta-minus Decay Radioisotopes.
|2 local.
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| 650 |
|
7 |
|a Cobalt Isotopes.
|2 local.
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| 650 |
|
7 |
|a Radiation Effects.
|2 local.
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| 650 |
|
7 |
|a Response Modifying Factors.
|2 local.
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| 650 |
|
7 |
|a Cobalt 60.
|2 local.
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| 650 |
|
7 |
|a Animals.
|2 local.
|
| 650 |
|
7 |
|a Sex Dependence.
|2 local.
|
| 650 |
|
7 |
|a Gamma Radiation.
|2 local.
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| 650 |
|
7 |
|a Rodents.
|2 local.
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| 650 |
|
7 |
|a Biological Effects.
|2 local.
|
| 650 |
|
7 |
|a Intermediate Mass Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Man.
|2 local.
|
| 650 |
|
7 |
|a Odd-odd Nuclei.
|2 local.
|
| 650 |
|
7 |
|a Statistics.
|2 local.
|
| 650 |
|
7 |
|a Risk Assessment.
|2 local.
|
| 650 |
|
7 |
|a Chronic Irradiation.
|2 local.
|
| 650 |
|
7 |
|a Radiations.
|2 local.
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| 650 |
|
7 |
|a Radioinduction.
|2 local.
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| 650 |
|
7 |
|a Delayed Radiation Effects.
|2 local.
|
| 650 |
|
7 |
|a Dose Rates.
|2 local.
|
| 650 |
|
7 |
|a Nuclei.
|2 local.
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| 650 |
|
7 |
|a Neoplasms.
|2 local.
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| 650 |
|
7 |
|a Years Living Radioisotopes.
|2 local.
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| 650 |
|
7 |
|a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..
|2 edbsc.
|
| 710 |
2 |
|
|a Alabama A & M University.
|4 res.
|
| 710 |
1 |
|
|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
0 |
|u http://www.osti.gov/servlets/purl/6933831/
|z Online Access
|
| 907 |
|
|
|a .b72134823
|b 03-07-23
|c 11-08-12
|
| 998 |
|
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|a web
|b 11-08-12
|c f
|d m
|e p
|f eng
|g alu
|h 0
|i 2
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| 956 |
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|a Information bridge
|
| 999 |
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|s d6fe07f4-2a4e-5133-8d38-1eb80d2e5053
|
| 952 |
f |
f |
|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:conf-780306-8
|h Superintendent of Documents classification
|i web
|n 1
|
