Protein quality control in neurodegenerative diseases [electronic resource] / Richard I. Morimoto, Yves Christen, editors.
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded protei...
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Full Text (via Springer) |
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Berlin ; New York :
Springer,
©2013.
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| Series: | Research and perspectives in Alzheimer's disease.
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| Subjects: |
MARC
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| 245 | 0 | 0 | |a Protein quality control in neurodegenerative diseases |h [electronic resource] / |c Richard I. Morimoto, Yves Christen, editors. |
| 260 | |a Berlin ; |a New York : |b Springer, |c ©2013. | ||
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent. | ||
| 337 | |a computer |b c |2 rdamedia. | ||
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| 490 | 1 | |a Research and perspectives in Alzheimer's disease. | |
| 505 | 0 | 0 | |g The |t regulation and function of the heat shock response / |r Eric Guisbert, Richard I. Morimoto --The |t endoplasmic reticulum unfolded protein response and neurodegeneration / |r David Ron -- |t Proteostasis and the aging pathways / |r Ian Nicastro, Andrew Dillin --The |t membrane sources of macroautophagy / |r Daniel J. Klionsky, Melinda A. Lynch-Day -- |t Selective autophagy in cellular quality control / |r Susmita Kaushik, Ana Maria Cuervo -- |t Quality control of proteins and organelles by autophagy / |r Noboru Mizushima --The |t role of the co-chaperone BAG3 in selective macroautophagy: implications for aging and disease / |r Christian Behl -- |t Predicting fates in models of neurodegenerative disease: longitudinal measures of protein homeostasis in live neurons / |r Steven Finkbeiner -- |t Therapeutic potential of longevity modulators as neuroprotective targets in neurodegenerative disease / |r Rafael Vazquez-Manrique, Cendrine Tourette --The |t interplay between the chaperonin TRiC and N-terminal region of Huntingtin mediates Huntington's Disease aggregation and pathogenesis / |r Koning Shen, Judith Frydman. |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a The Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code. | |
| 520 | |a The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Nervous system |x Degeneration |x Etiology. | |
| 650 | 0 | |a Proteins |x Conformation. |0 http://id.loc.gov/authorities/subjects/sh89006335. | |
| 700 | 1 | |a Morimoto, Richard I., |d 1952- |0 http://id.loc.gov/authorities/names/n88219233 |1 http://isni.org/isni/0000000083679741. | |
| 700 | 1 | |a Christen, Yves. |0 http://id.loc.gov/authorities/names/n79142490 |1 http://isni.org/isni/0000000381611497. | |
| 776 | 0 | 8 | |i Print version: |t Protein quality control in neurodegenerative diseases. |d Berlin ; London : Springer, 2012 |z 9783642279270 |w (OCoLC)800864611. |
| 830 | 0 | |a Research and perspectives in Alzheimer's disease. |0 http://id.loc.gov/authorities/names/n86723630. | |
| 856 | 4 | 0 | |u https://colorado.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-642-27928-7 |z Full Text (via Springer) |
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