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130208e19890201wau ot f0|||||eng|d |
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|a (TOE)ost6277861
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|a (TOE)6277861
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|a TOE
|c TOE
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| 049 |
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|a GDWR
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| 072 |
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|a 63
|2 edbsc
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| 086 |
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|a E 1.99:pnl-6833
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| 086 |
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|a E 1.99:pnl-6833
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| 088 |
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|a pnl-6833
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| 245 |
0 |
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|a Inhalation developmental toxicology studies
|h [electronic resource] :
|b Teratology study of methyl ethyl ketone in mice.
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| 260 |
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|a Richland, Wash. :
|b Pacific Northwest National Laboratory (U.S.) ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy,
|c 1989.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a computer
|b c
|2 rdamedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 500 |
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|a Published through the Information Bridge: DOE Scientific and Technical Information.
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| 500 |
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|a 02/01/1989.
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| 500 |
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|a "pnl-6833"
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| 500 |
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|a "DE89009563"
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| 500 |
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|a Weigel, R.J.; Rommereim, R.L.; Mast, T.J.; Evanoff, J.J.; Westerberg, R.B.; Dill, J.A.
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| 520 |
3 |
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|a Methyl ethyl ketone (MEK) is a widely used industrial solvent which results in considerable human exposure. In order to assess the potential for MEK to cause developmental toxicity in rodents, four groups of Swiss (CD-1) mice were exposed to 0, 400, 1000 or 3000 ppM MEK vapors, 7 h/day, 7 dy/wk. Ten virgin females and approx.30 plug-positive females per group were exposed concurrently for 10 consecutive days (6--15 dg for mated mice). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 18 dg. Uterine implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Exposure of pregnant mice to these concentrations of MEK did not result in apparent maternal toxicity, although there was a slight, treatment-correlated increase in liver to body weight ratios which was significant for the 3000-ppM group. Mild developmental toxicity was evident at 3000-ppM as a reduction in mean fetal body weight. This reduction was statistically significant for the males only, although the relative decrease in mean fetal body weight was the same for both sexes. 17 refs., 4 figs., 10 tabs.
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| 536 |
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|b AC06-76RL01830.
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| 650 |
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7 |
|a Litter Size.
|2 local.
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| 650 |
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7 |
|a Organic Compounds.
|2 local.
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| 650 |
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7 |
|a Document Types.
|2 local.
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| 650 |
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|a Comparative Evaluations.
|2 local.
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| 650 |
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|a Progress Report.
|2 local.
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| 650 |
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|a Ketones.
|2 local.
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| 650 |
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|a Mammals.
|2 local.
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| 650 |
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|a Mice.
|2 local.
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| 650 |
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|a Teratogenesis.
|2 local.
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| 650 |
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|a Time Dependence.
|2 local.
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| 650 |
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|a Intake.
|2 local.
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| 650 |
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7 |
|a Life Span.
|2 local.
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| 650 |
|
7 |
|a Prenatal Exposure.
|2 local.
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| 650 |
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|a Dose-response Relationships.
|2 local.
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| 650 |
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|a Inhalation.
|2 local.
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| 650 |
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|a Vertebrates.
|2 local.
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| 650 |
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|a Malformations.
|2 local.
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| 650 |
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|a Mortality.
|2 local.
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| 650 |
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7 |
|a Animals.
|2 local.
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| 650 |
|
7 |
|a Sex Dependence.
|2 local.
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| 650 |
|
7 |
|a Pathological Changes.
|2 local.
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| 650 |
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7 |
|a Toxicity.
|2 local.
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| 650 |
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|a Rodents.
|2 local.
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| 650 |
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7 |
|a Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat..
|2 edbsc.
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| 710 |
2 |
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|a Pacific Northwest Laboratory.
|4 res.
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| 710 |
2 |
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|a Pacific Northwest National Laboratory (U.S.).
|4 res.
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| 710 |
1 |
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
|
| 856 |
4 |
0 |
|u http://www.osti.gov/servlets/purl/6277861/
|z Online Access
|
| 907 |
|
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|a .b73080470
|b 03-07-23
|c 02-11-13
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| 998 |
|
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|a web
|b 02-11-13
|c f
|d m
|e p
|f eng
|g wau
|h 0
|i 1
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| 956 |
|
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|a Information bridge
|
| 999 |
f |
f |
|i ab723137-b801-5c4f-93ec-7f90e41b7cea
|s 9d314e18-af65-56b0-94eb-10822f6eb690
|
| 952 |
f |
f |
|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:pnl-6833
|h Superintendent of Documents classification
|i web
|n 1
|
