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Reactive oxygen species and the cardiovascular system [electronic resource] / Augusto C. Montezano and Rhian M. Touyz.

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Bibliographic Details
Online Access: Full Text (via Colloquium Digital Library)
Main Author: Montezano, Augusto C.
Other Authors: Touyz, Rhian M.
Format: Electronic eBook
Language:English
Published: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, ©2012.
Series:Colloquium series on integrated systems physiology ; #32.
Subjects:
Active oxygen > Physiological effect.
Oxidative stress.
Table of Contents:
  • 1. Introduction
  • 2. Redox molecules
  • 2.1 Superoxide and hydrogen peroxide
  • 2.2 Reactive nitrogen species (RNS)
  • 3. Production and metabolism of ROS in the cardiovascular system
  • 3.1 Xanthine oxidase
  • 3.2 Uncoupled nitric oxide synthase
  • 3.3 Mitochondrial respiratory enzymes
  • 3.4 Nox-family NAD(P)H oxidases
  • 3.4.1 Nox1
  • 3.4.2 Nox2
  • 3.4.3 Nox4
  • 3.4.4 Nox5
  • 4. Interactions between mitochondria and Noxs
  • 5. Distribution of Noxes in the vascular wall
  • 6. Regulation of Noxes
  • 7. Protecting against oxidative stress, antioxidant defenses
  • 7.1 Enzymatic antioxidants
  • 7.2 Non-enzymatic antioxidants
  • 8. How does oxidative stress cause disease?
  • 9. Oxidative stress and hypertension
  • 9.1 Production of ROS in the cardiovascular and renal systems in hypertension
  • 9.2 ROS and autonomic outflow and hypertension
  • 9.3 Oxidative stress in experimental hypertension
  • 9.4 Oxidative stress and clinical hypertension
  • 10. Antioxidant therapy and human hypertension
  • 11. NADPH oxidase and Nox isoforms as therapeutic targets, clinical potential
  • 12. Other strategies to reduce oxidative stress
  • 13. Assessing reactive oxygen species in the cardiovascular system
  • 13.1 Cytochrome C reduction
  • 13.2 Lucigenin-enhanced chemiluminescence
  • 13.3 Dihydroethidium and high-performance liquid chromatography
  • 13.4 Dichlorofluorescein and amplex red to measure H2O2
  • 13.5 Dihydrorhodamine oxidation to measure ONOO-
  • 13.6 Electron spin resonance
  • 14. Assessing ROS in clinical studies
  • 15. Conclusion
  • Acknowledgments
  • References
  • Author biographies.

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