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Clinical and molecular aspects of motor neuron disease / Johnathan Cooper-Knock, Thomas Jenkins, Pamela J. Shaw.

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Bibliographic Details
Online Access: Full Text (via Colloquium Digital Library)
Main Authors: Cooper-Knock, Johnathan, 1982- (Author), Jenkins, Thomas (Author), Shaw, Pamela J. (Author)
Format: eBook
Language:English
Published: San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.
Series:Colloquium series on genomic and molecular medicine ; # 4.
Subjects:
Amyotrophic lateral sclerosis.
Table of Contents:
  • 1. Clinical aspects of MND
  • 1.1 Historical Perspective
  • 1.2 Epidemiology
  • 1.3 Clinical features
  • 1.4 Clinical classification
  • 1.5 Diagnosis
  • 1.6 Differential diagnosis
  • 1.7 Management
  • 1.8 Unsuccessful treatments
  • 1.9 Prognosis
  • 2. Molecular aspects of MND
  • 2.1 Aetiology
  • 2.2 Mendelian MND
  • 2.2.1 SOD1-MND
  • 2.2.2
  • TARDBP-MND
  • 2.2.3
  • FUS-MND
  • 2.2.4
  • C9ORF72-MND
  • 2.3 Sporadic MND
  • 2.4 Proposed mechanisms of pathogenesis
  • 2.5 RNA processing
  • 2.6 Protein processing
  • 2.7 Protein processing and disease propagation
  • 2.8 Mitochondrial function
  • 2.9 Cytoskeleton and axonal transport
  • 2.10 Oxidative stress
  • 2.11 Lipid metabolism
  • 2.12 Non-neuronal cells and inflammation
  • 2.13 Conclusion
  • References
  • Author biographies
  • Titles of related Interest
  • Series of related Interest.

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