Hypoxia and cancer : biological implications and therapeutic opportunities / Giovanni Melillo, editor.
The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microe...
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Full Text (via Springer) |
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| Format: | eBook |
| Language: | English |
| Published: |
New York :
Springer,
2014.
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| Series: | Cancer drug discovery and development.
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| Subjects: |
Table of Contents:
- Part I. Biology
- Hypoxia and Breast Cancer Metastasis / Luana Schito and Gregg L. Semenza
- Hypoxia and the DNA Damage Response / Monica M. Olcina and Ester M. Hammond
- Emerging Roles of Non-Coding RNAs in the Hypoxic Response / Mircea Ivan, Xiaoling Zhong, Simona Greco and Fabio Martelli
- Hypoxia and Reactive Oxygen Species / Agnes Görlach
- Hypoxia and Gene Expression / Maria Carla Bosco and Luigi Varesio
- Carbonic Anhydrase IX: From Biology to Therapy / Silvia Pastorekova and Claudiu T. Supuran
- Part II. Imaging
- Imaging the Hypoxic Tumor Microenvironment in Preclinical Models / Mary-Keara Boss, Gregory M. Palmer and Mark W. Dewhirst
- Clinical Imaging of Hypoxia / Michael R. Horsman, DMSc, Morten Busk, Thomas Nielsen, Marianne Nordsmark and Jens Overgaard
- Part III. Therapy
- Hypoxia, Metastasis, and Antiangiogenic Therapies / Dietmar W. Siemann, Yao Dai and Michael R. Horsman
- The Unfolded Protein Response and Therapeutic Opportunities / Carly M. Sayers, Souvik Dey, Stacey L. Lehman and Constantinos Koumenis
- Small Molecules Targeting the VHL/Hypoxic Phenotype / Raymond J. Louie, Mercè Padró, Amato J. Giaccia and Denise A. Chan
- Hypoxia and Radiation Therapy / Marianne Nordsmark, Jan Alsner, Morten Busk, Jens Overgaard and Michael R. Horsman
- Prodrug Strategies for Targeting Tumour Hypoxia / William R. Wilson, Kevin O. Hicks, Jingli Wang and Frederik B. Pruijn
- Exploiting "Hif Addiction" For Cancer Therapy / Nicole D. Fer and Annamaria Rapisarda
- Clinical Exploitation of Hypoxia / Geoff S Higgins and Adrian L Harris.