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|a (TOE)ost1014168
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|a (TOE)1014168
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|a E 1.99:1014168
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|a E 1.99:1014168
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|a Breaking the Nanometer Barrier
|h [electronic resource] :
|b Progress in Biological Nanoscience, Measured One Molecule at a Time (How a Biophysicist Watches DNA Transcription)
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|a Washington, D.C. :
|b United States. Department of Energy. Office of Science ;
|a Oak Ridge, Tenn. :
|b distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
|c 2006.
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|a 1:23:29 :
|b digital, PDF file.
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|a text
|b txt
|2 rdacontent.
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|a computer
|b c
|2 rdamedia.
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|a online resource
|b cr
|2 rdacarrier.
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|a Published through SciTech Connect.
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|a 03/20/2006.
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|a SLAC Colloquium Series, SLAC National Accelerator Laboratory, Menlo Park, California, presented on March 20, 2006.
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|a Block, Stephen.
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|a A new field of scientific exploration - single molecule biophysics - is currently reshaping and redefining our understanding of the mechanochemistry of life. The development of laser-based optical traps, or 'optical tweezers,' has allowed for physiological assessments of such precision that bio-molecules can now be measured and studied one at a time. In this colloquium, Professor Block will present findings based on his group's construction of optical trapping instrumentation that has broken the nanometer barrier, allowing researchers to study single-molecule displacements on the Angstrom level. Focusing on RNA polymerase, the motor enzyme responsible for transcribing the genetic code contained in DNA, Block's group has been able to measure, in real time, the motion of a single molecule of RNA polymerase as it moves from base to base along the DNA template.
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|b AC02-76SF00515.
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|a Accuracy.
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|a Biophysics.
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|a Construction.
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|a Dna.
|2 local.
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|a Enzymes.
|2 local.
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|a Exploration.
|2 local.
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|a Fermilab Accelerator.
|2 local.
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|a Focusing.
|2 local.
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|a Genetics.
|2 local.
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|a Motors.
|2 local.
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|a Rna Polymerases.
|2 local.
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|a Stanford Linear Accelerator Center.
|2 local.
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|a Transcription.
|2 local.
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|a Trapping.
|2 local.
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|a Particle Accelerators.
|2 edbsc.
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|a SLAC National Accelerator Laboratory.
|4 res.
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|a United States.
|b Department of Energy.
|b Office of Science.
|4 spn.
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|a United States.
|b Department of Energy.
|b Office of Scientific and Technical Information.
|4 dst.
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|u http://www.osti.gov/scitech/biblio/1014168
|z Online Access
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|a .b77069390
|b 03-07-23
|c 04-22-14
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| 998 |
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|a web
|b 09-09-16
|c f
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|e p
|f eng
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|h 0
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|a Information bridge
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|s 26ab0c86-052d-56fe-8fdd-ed9dd0bb1200
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| 952 |
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|p Can circulate
|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e E 1.99:1014168
|h Superintendent of Documents classification
|i web
|n 1
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