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MFG-E8 and inflammation / Ping Wang, editor.

After the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research. In MFG-E8 and Inflammation, the editor and con...

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Bibliographic Details
Online Access: Full Text (via Springer)
Other Authors: Wang, Ping (Editor)
Format: eBook
Language:English
Published: Dordrecht ; New York : Springer, [2014]
Subjects:
Milkfat.
Inflammation.
Table of Contents:
  • Preface
  • About the Editor
  • Contents
  • Contributors
  • Chapter 1: MFG-E8: Origin, Structure, Expression, Functions and Regulation
  • 1 Origin, Primary Structure and Molecular Evolution
  • 2 Glycosylation
  • 3 Domain Structure and Molecular Functions
  • 3.1 The EGF-Like Domain with RGD Motif
  • 3.2 The F5/8-type C Domains
  • 3.3 Medin Peptide and Amyloid
  • 3.4 Binding with Extracellular Matrix
  • 3.5 P/T-Rich Domain of Murine MFG-E8
  • 4 Gene Expression
  • 4.1 Expression Profiling by Genomic Studies
  • 4.2 Regulation of Gene Expression.
  • 5 Physiological Function5.1 Opsonization and Enhancement of Phagocytosis
  • 5.2 Autoimmunity, Macrophage Regulation and  Immunosuppression
  • 5.3 Angiogenesis and Tumorigenesis
  • 5.4 Maintenance of Epithelium Integrity (Intestinal and  Epididymal Epithelia)
  • 5.5 Mammary Gland Development and Involution
  • References
  • Chapter 2: MFG-E8 as a Marker for Apoptotic, Stressed and Activated Cells
  • 1 Phospholipid Asymmetry in Cellular Membranes
  • 2 MFG-E8 as a Phosphatidylserine Recognition Tool
  • 3 Lactadherin as a Diagnostic Marker.
  • 4 Lactadherin and Blood CoagulationReferences
  • Chapter 3: Role of MFG-E8 in Protection of Intestinal Epithelial Barrier Function and Attenuation of  Intestinal Inflammation
  • 1 Introduction
  • 2 MFG-E8 and Apoptotic Cell Clearance
  • 3 Intestinal Epithelial Barrier
  • 4 MFG-E8 and Intestinal Epithelial Barrier Function
  • 4.1 MFG-E8 Plays an Important Role in Maintaining Intestinal Epithelial Homeostasis
  • 4.2 MFG-E8 and Acute Intestinal Injury
  • 4.3 MFG-E8 and Chronic Intestinal Injury
  • 5 Summary
  • References.
  • Chapter 4: MFG-E8 in the Blood Cell Homeostasis and  Coagulation1 Introduction
  • 2 Phospholipid in Coagulation
  • 3 Lactadherin Binding to PS Resembles Factor VIII and  Factor V Binding to Phospholipid
  • 4 Lactadherin as an Anticoagulant
  • 5 Lactadherin Deficient Mice are Prothombotic
  • 6 Lactadherin and Clearance of Blood Cells
  • 7 Red Blood Cell Senescence and PS Exposure
  • 8 PS Exposure in Sickle Red Blood Cells
  • 9 Role of Lactadherin in Red Blood Cell Clearance
  • 10 Microvesicles in Circulation
  • 11 Lactadherin and Microvesicles.
  • 12 Lactadherin and Atherosclerosis13 Conclusion
  • References
  • Chapter 5: MFG-E8 in the Vascular System
  • 1 Introduction
  • 2 MFG-E8 and Angiogenesis
  • 3 MFG-E8 and Atherosclerosis
  • 3.1 Anti-atherogenic Properties of MFG-E8
  • 3.2 A Pathogenic Role for MFG-E8 in Vascular Disease?
  • 4 MFG-E8 and Aneurysm
  • 5 MFG-E8 and Ischemia/Reperfusion (I/R) Injury
  • 6 Conclusion
  • References
  • Chapter 6: Autoimmune Diseases and the Role of  MFG-E8
  • 1 Introduction: Clearance of Apoptotic Cells
  • 1.1 “Find-Meâ€? Signals.

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