Competitive effects of erythropoietin and colony stimulating factor [electronic resource]
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| Online Access: |
Online Access |
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| Format: | Government Document Electronic eBook |
| Language: | English |
| Published: |
Washington, D.C. : Oak Ridge, Tenn. :
United States. Department of Energy. ; distributed by the Office of Scientific and Technical Information, U.S. Department of Energy,
1977.
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| Subjects: |
| Abstract: | Recipient mice were x-irradiated and injected with nucleated cells one to five hrs later. Bone marrow cells were cultured and colonies were scored with a dissecting microscope. When plethoric mice or rats were used either as hosts for CFU-stimulating assay or to supply marrow for experiments in vitro, they were subjected to 0.5 atmosphere for 4 to 6 weeks. Results showed that the responses to erythropoietin or colony stimulating factor of marrow cells especially from plethoric animals, were modulated by the presence of the other factor. The degree of suppression of erythroid function by the colony stimulating factor and of colony appearance by erythropoietin was dependent on the relative amounts of the two substances. Data indicate that, when erythropoietin stimulates erythroid burst formation in the presence of colony stimulating factor, erythroid differentiation occurs at the expense of colony formation. (HLW) |
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| Item Description: | Published through SciTech Connect. 01/01/1977. "conf-770986--1" Cold Springs Harbor symposium, Cold Springs Harbor, NY, USA, Sep 1977. Goldwasser, E.; Van Zant, G. Chicago Univ., Ill. (USA). Department of Biochemistry. Franklin McLean Memorial Research Inst., Chicago, Ill. (USA) |
| Physical Description: | Pages: 28 : digital, PDF file. |