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141016s2014 caua foab 000 0 eng d |
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|a 9781615046638
|q electronic
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|a 10.4199/C00114ED1V02Y201407GBD006
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|a cdlls201407gbd006
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|a (OCoLC)893205596
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|a (CaBNVSL)swl00404123
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|a CaBNVSL
|b eng
|e rda
|c CaBNVSL
|d CaBNVSL
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4 |
|a QH428
|b .M655 2014
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| 100 |
1 |
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|a Moitra, Karobi,
|e author.
|0 http://id.loc.gov/authorities/names/no2012072313
|1 http://isni.org/isni/0000000370644197.
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| 245 |
1 |
2 |
|a A journey through genetics.
|n Part II /
|c Karobi Moitra.
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| 264 |
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1 |
|a San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) :
|b Morgan & Claypool,
|c 2014.
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| 300 |
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|a 1 PDF (ix, 71 pages) :
|b illustrations.
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| 336 |
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|a text
|b txt
|2 rdacontent.
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| 337 |
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|a electronic
|2 isbdmedia.
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| 338 |
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|a online resource
|b cr
|2 rdacarrier.
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| 490 |
1 |
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|a Colloquium series on the genetic basis of human disease,
|x 2168-4022 ;
|v # 6.
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| 500 |
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|a Part of: Colloquium digital library of life sciences.
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| 504 |
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|a Includes bibliographical references (pages 69-70)
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| 505 |
0 |
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|a History of genetics timeline (part 2) --
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| 505 |
8 |
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|a 1. The age of the operon: the regulation of gene expression in E. coli -- 1.1 The operon model: the lactose operon of E. coli -- 1.2 Structural elements of the Lac operon -- 1.2.1 Structural genes (Lac Z, Lac Y, Lac A) -- 1.2.2 The operator gene (Lac O) -- 1.2.3 The regulator gene (Lac I) -- 1.3 Functional regulation of the lactose operon -- 1.3.1 The role of induction and repression in the Lac operon -- 1.3.2 Attachment of the RNA polymerase -- 1.3.3 Transcription of the structural genes -- 1.4 A short educational skit based on the lactose operon: I need energy: a tale of two sugars -- 1.5 What would happen if both glucose and lactose were present in the medium? --
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| 505 |
8 |
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|a 2. Genetic diversity: cheetah chatter -- 2.1 The journey into Africa -- 2.2 Proteins in the cheetah's blood were separated and analyzed using a technique called protein gel electrophoresis -- 2.3 A second line of evidence from MHC proteins and skin grafts -- 2.4 Genetic diversity -- 2.5 Cheetahs and the bottleneck effect --
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| 505 |
8 |
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|a 3. Gene cloning and recombinant DNA technology -- 3.1 Gene manipulation/genetic engineering can be divided into two steps (figure 3.1) -- 3.2 Characteristic features of cloning vectors -- 3.3 Applications of genetic engineering --
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| 505 |
8 |
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|a 4. Applications of genetic engineering, resurrecting the influenza virus -- 4.1 The journey -- 4.1.1 Resurrection -- 4.1.2 The one that got away -- 4.1.3 Reverse engineering a killer virus --
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| 505 |
8 |
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|a 5. The human journey -- 5.1 Spencer Wells and the genographic project -- 5.1.1 In the beginning -- 5.2 How do we know that this amazing journey started in Africa? -- 5.2.1 Mapping markers on Y chromosomes -- 5.2.2 STR markers -- 5.2.3 Mitochondrial Eve and female mitochondrial markers -- 5.2.4 Mapping single nucleotide polymorphisms on mitochondrial DNA -- 5.2.5 The journey of the y chromosome (figure 5.5) -- 5.2.6 The journey out of Africa (the M168 marker) -- 5.2.7 The first route out of Africa and on to Australia -- 5.2.8 Journeying on to Australia (M130 marker) -- 5.2.9 The second route out of Africa to Central Asia -- 5.2.10 Forty thousand years ago modern humans reach Central Asia -- 5.2.11 Following the M45 (migrating East) -- 5.2.12 The longest journey: 50,000 years and people reach South America (the M3 marker) -- 5.2.13 What did you learn from this journey? --
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| 505 |
8 |
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|a 6. The three-dimensional folding of the genome -- 6.1 Beads on a string -- 6.1.1 The nucleosome concept: the first level of folding -- 6.1.2 Nucleosomes unraveled -- 6.2 Linker histone and linker DNA -- 6.3 Higher-order folding of chromatin -- 6.3.1 The 30-nm fiber of chromatin -- 6.3.2 Solenoid model -- 6.3.3 Conventional model -- 6.4 Erez Lieberman Aiden and the three-dimensional folding of the genome -- 6.5 Hi-C in detail: a method to study the three-dimensional architecture of genomes -- 6.5.1 Hi-C method -- 6.6 "The genome is Scottish!" Eric Lander -- 6.6.1 Why is the genome Scottish? Of Ramen noodles and tangled ear buds -- 6.6.2 The old theory, the equilibrium globule debunked --
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| 505 |
8 |
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|a 7. The human genome project and beyond -- 7.1 Goals of the human genome project -- 7.2 Cost of the human genome project -- 7.2.1 The race to the human genome -- 7.3 How was the human genome sequenced? -- 7.4 Sequencing strategies -- 7.4.1 Hierarchical shotgun sequencing strategy -- 7.4.2 Whole-genome shot gun sequencing -- 7.5 The human genome project: what did we learn? -- 7.6 Early DNA sequencing technologies -- 7.6.1 Sanger sequencing -- 7.6.2 Dye terminator cycle sequencing -- 7.6.3 Beyond the human genome project: next-generation sequencing strategies -- 7.6.4 Next-generation sequencing (NGS) technologies -- 7.7 Applications of NextGen sequencing --
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| 505 |
8 |
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|a References -- Author biography.
|
| 520 |
3 |
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|a This is designed to continue on the incredible journey initiated in Part I to explore the exciting discoveries in genetics and molecular biology. In Part I, the reader embarked on a genetic odyssey that started with the "Father of Genetics," Gregor Mendel, and culminated in the invention of one of the most powerful tools in molecular biology--the polymerase chain reaction. The second part of the book will take the reader on a journey to explore the frontiers of genetic diversity, gene cloning, the human journey, and the human genome project! The book is targeted toward undergraduate non-majors and also as a "companion" to a standard genetics textbook for biology majors. The book will also prove to be useful for anyone that wants to understand the stories behind the science of genetics.
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| 538 |
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|a Mode of access: World Wide Web.
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| 538 |
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|a System requirements: Adobe Acrobat reader.
|
| 588 |
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|a Title from PDF title page (viewed on October 16, 2014)
|
| 650 |
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0 |
|a Genetics
|x History.
|0 http://id.loc.gov/authorities/subjects/sh2008105127.
|
| 650 |
|
0 |
|a DNA
|x History.
|
| 650 |
|
0 |
|a Human genome.
|0 http://id.loc.gov/authorities/subjects/sh94002900.
|
| 776 |
0 |
8 |
|i Print version:
|z 9781615046621.
|
| 830 |
|
0 |
|a Colloquium series on the genetic basis of human disease ;
|v # 6.
|0 http://id.loc.gov/authorities/names/no2013137458.
|
| 856 |
4 |
8 |
|3 Abstract with links to full text
|u https://colorado.idm.oclc.org/login?url=http://dx.doi.org/10.4199/C00114ED1V02Y201407GBD006
|z Full Text (via Colloquium Digital Library)
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|c 04-03-15
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|a University of Colorado Boulder
|b Online
|c Online
|d Online
|e QH428 .M655 2014
|h Library of Congress classification
|i web
|n 1
|
