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The Human Teratomas [electronic resource] : Experimental and Clinical Biology / edited by Ivan Damjanov, Barbara B. Knowles, Davor Solter.

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Bibliographic Details
Online Access: Full Text (via Springer)
Main Author: Damjanov, Ivan
Other Authors: Knowles, Barbara B., Solter, Davor
Format: Electronic eBook
Language:English
Published: Totowa, NJ : Humana Press, 1983.
Series:Contemporary biomedicine ; 3.
Subjects:
Medicine.
Pathology.
Teratoma.
Table of Contents:
  • 1 History of Teratomas
  • Early Morphologic and Clinical Studies of Ovarian Teratomas
  • Theories of the Origin of Teratomas
  • Early Morphologic and Clinical Studies of Testicular Teratomas
  • Extragonadal Teratomas
  • Teratomas in Animals
  • Experimental Studies
  • References
  • 2 The Pathology of Human Teratomas
  • Classification of Germ Cell Tumors
  • Origin of Teratomas
  • Testicular Teratomas
  • Ovarian Teratomas
  • Extragonadal Teratomas
  • Histopathology
  • Embryonal Carcinoma
  • Somatic Tissues
  • Extraembryonic Tissues
  • Nonneoplastic Components of Teratomas
  • Variant Forms of Teratomas and Related Lesions
  • Monophyletic or Unilaterally Differentiated Teratomas
  • Mixed Teratoid Tumors
  • Mixed Mullerian Tumors
  • Fetus in Fetu
  • Site of Origin of Teratomas
  • Ovarian Teratomas
  • Testicular Teratomas
  • Sacrococcygeal Teratomas
  • Retroperitoneal Teratomas
  • Mediastinal Teratomas
  • Teratomas of the Neck
  • Intracranial Teratomas
  • Teratomas in Unusual Locations
  • Associated Lesions and Abnormalities
  • Twinning
  • Association of Teratomas and Malformations
  • Chromosomal Abnormalities and Genetic Predisposition to Teratomas
  • Disturbances in the Immune System
  • References
  • 3 The Origin of Teratomas
  • Dermoid Cyst (Benign Cystic Teratoma) of the Ovary
  • Genetic Evidence in Favor of a Postmeiotic (Parthenogenic) Origin of Dermoid Cysts
  • Teratomas of Testis
  • The Application of Genetic Techniques to Germ Cell Tumors of the Testis
  • Germ Cell Tumors of the Pineal Gland (and Its Environs)
  • Teratomas of the Mediastinum
  • The Origin of Teratomas of the Pineal Gland, Mediastinum, and Sacrococcygeal Region in the Neonatal Period and in Infancy
  • Genetic and Chromosomal Observations on Extragonadal Teratomas and on Individuals Who Have Extragonadal Teratomas
  • Teratomas Associated with Sex Chromosome Abnormalities
  • X Chromosome Differentiation, Barr Body Formation, and Teratomas
  • Discussion
  • References
  • 4 The Epidemiology of Human Teratomas
  • Frequency
  • Teratomas of the Ovary
  • Testicular Teratomas
  • Sacrococcygeal and Presacral Teratomas
  • Mediastinal Teratomas
  • Retroperitoneal Teratomas
  • Renal Teratomas
  • Intracranial Teratomas
  • Intraspinal Teratomas
  • Thyroid and Cervical Teratomas
  • Nasopharyngeal Teratomas
  • Cardiac, Gastric, Orbital, Hepatic, and Uterine Teratomas
  • Conclusions
  • References
  • 5 Malignant Alteration in Benign Teratomas
  • Ovary
  • Squamous Cell Carcinoma
  • Age and Incidence
  • Symptoms
  • Gross Pathology
  • Histology
  • Spread
  • Diagnosis and Treatment
  • Prognosis
  • Carcinoid
  • Adenocarcinoma
  • Malignant Melanoma
  • Sarcoma
  • Miscellaneous Tumors
  • Etiology and Pathogenesis of Malignant Alteration
  • Malignant Alteration in Extraovarian Teratomas
  • References
  • 6 The Metastasis of Human Teratomas
  • Metastasis of Germ Cell Tumors of the Testis
  • Incidence and Natural History of Metastasis
  • Experimental Data
  • Patterns of Metastasis
  • History of Metastases
  • Effect of Chemotherapy on Metastasis
  • Experimental Data
  • Metastasis of Germ Cell Tumors of the Ovary
  • Metastasis of Extragonadal Germ Cell Tumors
  • Conclusions
  • References
  • 7 Neural Tissues in Human Teratomas
  • Frequency of Nervous Tissue in Teratomas
  • Types of Neuroectodermal Tissues Present in Teratomas
  • Embryonal and Fetal Structures and Tissues
  • Mature Structures and Tissues
  • Reactive Phenomena in Teratoid Nervous Tissue
  • Implants and Neurogenic Metastases in Teratomas
  • Ultrastructural Findings in Teratoid Neuroectodermal Tissues
  • Clinicopathological Significance of the Neural Components of Teratomas
  • References
  • 8 Biological Markers of Human Teratomas and Related Germ Cell Tumors
  • Pathology
  • Malignant Teratomas
  • Seminoma
  • Immunocytochemical Approach
  • Localization of Placental Proteins
  • Human Chorionic Gonadotropin (HCG)
  • Other Placental Proteins
  • Markers of Yolk Sac Differentiation
  • Alphafetoprotein (AFP)
  • Other Yolk Sac Products
  • Fibronectin
  • Carcinoembryonic Antigen (CEA)
  • Epithelial Membrane Antigen (EMA)
  • Ferritin
  • Lactate Dehydrogenase
  • Tumors Devoid of Distinct Markers
  • Radioimmunolocalization
  • Multiple Markers
  • Classification of Testicular Tumors
  • References
  • 9 Endocrine Aspects of Germ Cell Tumors
  • Mechanisms Underlying Endocrine Manifestations
  • Associated Clinical Syndromes
  • Syndromes Associated with HCG Production
  • Syndromes Arising from Steroid Hormone Production in the Absence of HCG
  • Syndromes Resembling Those of Thyroid Hyperfunction
  • Carcinoid Syndrome
  • Syndromes of Ectopic Hormone Secretion
  • References
  • 10 Polypeptide Hormone-Producing Cells in Human Teratomas
  • Testicular Teratomas
  • Ovarian Teratomas
  • Related Ovarian Neoplasms
  • Ovarian Carcinoids
  • Cystic Mucinous Tumors
  • Biological Implications and Clinical Significance of Polypeptide Hormone-Producing Cells in Teratomas
  • References
  • 11 Chemotherapy of Teratomas
  • VAB-6 Combination Chemotherapy in Disseminated Cancer of the Testis
  • Primary Mediastinal Germ Cell Tumors
  • Germ Cell Tumors of the Ovary
  • Adjuvant VAB-6 Chemotherapy Regimen in Resected Stage II-B Testis Cancer
  • Concluding Remarks
  • References
  • 12 Human Testicular Germ Cell Tumors In Vitro
  • Cell Lines from Human Testicular Germ Cell Tumors
  • Some Characteristics of the Cell Lines
  • Embryonal Carcinoma Lines
  • Other Cell Lines from Testicular Germ Cell Tumors
  • Production of Tumors in Athymic Mice
  • Cytogenetics
  • Virus Production by Human EC Cells
  • Conclusion
  • References
  • 13 The Characteristics of Cell Lines Derived from Human Germ Cell Tumors
  • Human Teratoma Xenograft Lines
  • Human Teratocarcinoma Cell Lines Established In Vitro
  • Biochemical Properties
  • Major Histocompatibility Antigens
  • Embryonic Antigens
  • SSEA-3
  • Alkaline Phosphatase (ALP)
  • Conclusion
  • References
  • 14 Human
  • Mouse Teratocarcinoma Hybrids: A Tool for Analysis of Gene Activity in Early Human Development
  • Production of Microcell and Conventional Hybrids
  • Induction of Differentiation in Human
  • Mouse Teratocarcinoma Hybrids
  • Reexpression of Human Malic Enzyme by MCP-6 and the PCG Hybrids
  • The Expression of HLA-A, B, C in Human EC Cell Lines and MCP-6
  • Analysis of X-Inactivation Using Somatic Cell Genetics
  • Isolation of Developmentally Regulated Human DNA Sequences
  • Summary and Conclusions
  • References
  • 15 Experimental Mouse Teratocarcinoma: A Model for Human Teratocarcinoma?
  • Origin of Mouse Teratocarcinoma
  • Nature of Teratocarcinoma Stem Cells
  • Regulation of Teratocarcinogenesis
  • Comparison of Mouse and Human ECC
  • Concluding Remarks
  • References.

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