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The Resonant Recognition Model of Macromolecular Bioactivity [electronic resource] : Theory and Applications / by Irena Cosic.

Biological processes in any living organism are based on selective interactions be­ tween particular biomolecules. In most cases, these interactions involve and are driven by proteins, which are the main conductors of any life process within the organism. The physical nature of these interactions is...

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Bibliographic Details
Online Access: Full Text (via Springer)
Main Author: Cosic, Irena
Format: Electronic eBook
Language:English
Published: Basel : Birkhäuser Basel, 1997.
Series:BioMethods.
Subjects:
Life sciences.
Medicine.
Table of Contents:
  • 1 Introduction
  • 1.1 Structure-function relationships in proteins and DNA: definition of the problem
  • 1.2 Existing approaches and their limitations
  • 1.3 Novelty of the RRM model
  • 1.4 Applications of the RRM
  • 2 RRM Basic Concepts
  • 2.1 Definition of macromolecular functional characteristics: characteristic frequency
  • 2.2 Problems in FFT calculations within the RRM
  • 3 The Physical Meaning of the RRM
  • 3.1 Charge transfer through the protein backbone
  • 3.2 Correlation of the RRM characteristic frequency with absorption spectra of light-absorbing proteins
  • 3.3 Correlation of RRM characteristic frequency with low-intensity light effects on cell proliferation
  • 3.4 Correlation between predicted and measured characteristic frequency of chymotrypsin activation
  • 3.5 Photoreceptors with similar structures but different absorptions can be distinguished using the RRM
  • 3.6 Frequency range of macromolecular interactions
  • 4 Relation Between the RRM and 3D Protein Structures
  • 4.1 Definition of "hot spots" in terms of the RRM
  • 4.2 Example of heme-containing proteins
  • 4.3 Discussion
  • 5 Prediction of Functionally Active Sites and Functional Mutations
  • 5.1 Hot spot predictions in DNA: example of the SV40 enhancer
  • 5.2 Hot spot predictions in proteins: example of IL-2
  • 5.3 Hot spot predictions in EGF
  • 5.4 Active site prediction: example of protease-protease inhibitor interactions
  • 5.5 Oncogenes and their activity: example of ras proteins
  • 5.6 Definition of sequence function
  • 6 Protein Interactions
  • 6.1 Protein-protein interactions: frequency requirements
  • 6.2 Protein-protein interactions: phase requirements
  • 6.3 Protein-DNA interactions
  • 7 Bioactive Peptide Design
  • 7.1 Procedures: example of design of glucagon analogues
  • 7.2 NGF analogue design and possible applications
  • 7.3 Design of FGF analogues and application in limiting solid tumour growth
  • 7.4 HIV-related peptides that mimic HIV immunogenicity
  • 7.5 Activity of HIV-1-inhibiting peptides
  • 7.6 New concept of HIV activity
  • 8 Conclusions
  • 8.1 New concept in molecular biology, new point of view
  • 8.2 Advances in theory: macromolecular physics
  • 8.3 Advances in molecular biology; design of new pharmaceuticals
  • References.

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